Literature DB >> 2241946

Inhibition of TGF alpha-induced second messengers by anti-EGF receptor antibody-425.

U Murthy1, D J Rieman, U Rodeck.   

Abstract

Monoclonal antibody 425 binds to a protein epitope of the human EGF receptor and blocks EGF dependent functions such as EGF receptor phosphorylation and mitogenesis (1). We now show that MAb 425 blocks TGF alpha-induced second messenger signals, namely inositol 1,4,5 triphosphate and Ca2+ in two carcinoma cell lines, A 431 and SW-948. In this study we have further characterized the specificity of this antibody for inhibiting TGF alpha induced mitogenesis in MRC-5, a EGF-receptor expressing fibroblast cell line.

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Year:  1990        PMID： 2241946     DOI： 10.1016/0006-291x(90)90696-k

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  4 in total

1.  Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.

Authors:  M Jost; T M Huggett; C Kari; U Rodeck
Journal:  Mol Biol Cell       Date:  2001-05       Impact factor: 4.138

2.  Regulation of Bcl-xL expression in human keratinocytes by cell-substratum adhesion and the epidermal growth factor receptor.

Authors:  U Rodeck; M Jost; J DuHadaway; C Kari; P J Jensen; B Risse; D L Ewert
Journal:  Proc Natl Acad Sci U S A       Date:  1997-05-13       Impact factor: 11.205

3.  A 34-kd protein with strong homology to ras-like proteins inhibits epidermal growth factor activity.

Authors:  D S Strayer; J Mathew
Journal:  Am J Pathol       Date:  1993-04       Impact factor: 4.307

4.  Dose-dependent access of murine anti-epidermal growth factor receptor monoclonal antibody to tumor cells in patients with advanced laryngeal and hypopharyngeal carcinoma.

Authors:  H Bier; K A Reiffen; I Haas; P Stasiecki
Journal:  Eur Arch Otorhinolaryngol       Date:  1995       Impact factor: 2.503
  4 in total

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