BACKGROUND: Chronic kidney disease (CKD) has been demonstrated to be associated with adverse clinical outcomes for patients with coronary artery disease (CAD). However, data on relation of CKD and stent thrombosis (ST) after drug-eluting stent (DES) implantation are limited. OBJECTIVES: This study was designed to examine whether CKD is associated with higher incidence of ST after elective coronary DES implantation compared with patients with normal renal function. METHODS: We consecutively enrolled 2,862 patients undergoing elective percutaneous coronary intervention (PCI) with DES. Demographic and clinical data were collected preoperatively. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 ml/min, calculated using the modified MDRD equation. The primary outcome was 1-year definite or probable ST. RESULTS: Four hundred and forty-five participants (15.5%) had CKD before procedure. The incidence of 1-year definite or probable ST was significantly higher in CKD patients compared with patients with normal renal function (1.8% vs. 0.6%, P = 0.014). After adjustment for multiple clinical and biochemical covariates, CKD was an independent predictor of 1-year definite or probable ST (hazard rate [HR] 0.396, 95% CI 0.165-0.951, P = 0.038). CONCLUSION: CKD is significantly associated with increased incidence of 1-year definite or probable ST in patients undergoing PCI with DES.
BACKGROUND:Chronic kidney disease (CKD) has been demonstrated to be associated with adverse clinical outcomes for patients with coronary artery disease (CAD). However, data on relation of CKD and stent thrombosis (ST) after drug-eluting stent (DES) implantation are limited. OBJECTIVES: This study was designed to examine whether CKD is associated with higher incidence of ST after elective coronary DES implantation compared with patients with normal renal function. METHODS: We consecutively enrolled 2,862 patients undergoing elective percutaneous coronary intervention (PCI) with DES. Demographic and clinical data were collected preoperatively. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 ml/min, calculated using the modified MDRD equation. The primary outcome was 1-year definite or probable ST. RESULTS: Four hundred and forty-five participants (15.5%) had CKD before procedure. The incidence of 1-year definite or probable ST was significantly higher in CKD patients compared with patients with normal renal function (1.8% vs. 0.6%, P = 0.014). After adjustment for multiple clinical and biochemical covariates, CKD was an independent predictor of 1-year definite or probable ST (hazard rate [HR] 0.396, 95% CI 0.165-0.951, P = 0.038). CONCLUSION: CKD is significantly associated with increased incidence of 1-year definite or probable ST in patients undergoing PCI with DES.
Authors: Wojciech Wańha; Damian Kawecki; Tomasz Roleder; Aleksandra Pluta; Kamil Marcinkiewicz; Beata Morawiec; Janusz Dola; Sylwia Gładysz; Tomasz Pawłowski; Grzegorz Smolka; Andrzej Ochała; Ewa Nowalany-Kozielska; Wojciech Wojakowski Journal: Cardiorenal Med Date: 2016-12-09 Impact factor: 2.041
Authors: Moshe Shashar; Mostafa E Belghasem; Shinobu Matsuura; Joshua Walker; Sean Richards; Faisal Alousi; Keshab Rijal; Vijaya B Kolachalama; Mercedes Balcells; Minami Odagi; Kazuo Nagasawa; Joel M Henderson; Amitabh Gautam; Richard Rushmore; Jean Francis; Daniel Kirchhofer; Kumaran Kolandaivelu; David H Sherr; Elazer R Edelman; Katya Ravid; Vipul C Chitalia Journal: Sci Transl Med Date: 2017-11-22 Impact factor: 17.956
Authors: Omar K Siddiqi; Kyle J Smoot; Alyssa B Dufour; Kelly Cho; Melissa Young; David R Gagnon; Samantha Ly; Sara Temiyasathit; David P Faxon; J Michael Gaziano; Scott Kinlay Journal: Heart Date: 2015-07-24 Impact factor: 5.994
Authors: Mahmut Uluganyan; Gurkan Karaca; Turker Kemal Ulutas; Ahmet Ekmekci; Eyup Tusun; Ahmet Murat; Bayram Koroglu; Huseyin Uyarel; Nijad Bakhshaliyev; Mehmet Eren Journal: J Clin Med Res Date: 2016-02-27