Literature DB >> 2241933

Telomeres, telomerase and senescence.

C W Greider1.   

Abstract

Eukaryotic chromosomes end with tandem repeats of simple sequences. These GC rich repeats allow telomere replication and stabilize chromosome ends. Telomere replication involves an equilibrium of sequence loss and addition at the ends of chromosomes. Repeats are added de novo by telomerase, an unusual DNA polymerase. Telomerase is an RNP in which an essential RNA component provides the template for the added telomere repeats. Telomere length maintenance plays an essential role in cell viability.

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Year:  1990        PMID： 2241933     DOI： 10.1002/bies.950120803

Source DB:  PubMed          Journal:  Bioessays        ISSN： 0265-9247            Impact factor:   4.345


  58 in total

1.  Transplantation of adrenocortical cells.

Authors:  P J Hornsby
Journal:  Rev Endocr Metab Disord       Date:  2001-08       Impact factor: 6.514

2.  Does a sentinel or a subset of short telomeres determine replicative senescence?

Authors:  Ying Zou; Agnel Sfeir; Sergei M Gryaznov; Jerry W Shay; Woodring E Wright
Journal:  Mol Biol Cell       Date:  2004-06-04       Impact factor: 4.138

Review 3.  A challenge for the future: aging and HIV infection.

Authors:  Tammy M Rickabaugh; Beth D Jamieson
Journal:  Immunol Res       Date:  2010-12       Impact factor: 2.829

4.  Formation of novel hairpin structures by telomeric C-strand oligonucleotides.

Authors:  S Ahmed; E Henderson
Journal:  Nucleic Acids Res       Date:  1992-02-11       Impact factor: 16.971

5.  Recovery from stress is a function of age and telomere length.

Authors:  Graham M Strub; Amy Depcrynski; Lynne W Elmore; Shawn E Holt
Journal:  Cell Stress Chaperones       Date:  2008-05-20       Impact factor: 3.667

6.  Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest.

Authors:  L C Huang; K C Clarkin; G M Wahl
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205

7.  Normal human chromosomes have long G-rich telomeric overhangs at one end.

Authors:  W E Wright; V M Tesmer; K E Huffman; S D Levene; J W Shay
Journal:  Genes Dev       Date:  1997-11-01       Impact factor: 11.361

8.  BRG1, the ATPase subunit of SWI/SNF chromatin remodeling complex, interacts with HDAC2 to modulate telomerase expression in human cancer cells.

Authors:  Shu Wu; Yuanlong Ge; Laiqiang Huang; Haiying Liu; Yong Xue; Yong Zhao
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534

9.  Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes.

Authors:  Steven Russell Fauce; Beth D Jamieson; Allison C Chin; Ronald T Mitsuyasu; Stan T Parish; Hwee L Ng; Christina M Ramirez Kitchen; Otto O Yang; Calvin B Harley; Rita B Effros
Journal:  J Immunol       Date:  2008-11-15       Impact factor: 5.422

10.  Molecular cloning and characterization of the zebrafish (Danio rerio) telomerase catalytic subunit (telomerase reverse transcriptase, TERT).

Authors:  Benson Wui-Man Lau; Anderson On-Lam Wong; George Sai-Wah Tsao; Kwok-Fai So; Henry Ka-Fun Yip
Journal:  J Mol Neurosci       Date:  2007-09-19       Impact factor: 3.444
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