Literature DB >> 2241928

Quantitative control analysis of branched-chain 2-oxo acid dehydrogenase complex activity by feedback inhibition.

B Boyer1, R Odessey.   

Abstract

The potential for branched-chain 2-oxo acid dehydrogenase complex (BCOADC) activity to be controlled by feedback inhibition was investigated by calculating the Elasticity Coefficients for several feedback inhibitors. We suggest that feedback inhibition is a quantitatively important regulatory mechanism by which branched-chain 2-oxo acid dehydrogenase activity is regulated. The potential for control of enzyme activity is greater for NADH than for the acyl-CoA products, and suggests that factors that alter the redox potential may physiologically regulate BCOADC activity through a feedback inhibitory mechanism in vivo. Local pH may also be an important regulatory control factor.

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Year:  1990        PMID： 2241928      PMCID： PMC1149586          DOI： 10.1042/bj2710523

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  25 in total

1.  Determination of mitochondrial/cytosolic metabolite gradients in isolated rat liver cells by cell disruption.

Authors:  M E Tischler; P Hecht; J R Williamson
Journal:  Arch Biochem Biophys       Date:  1977-05       Impact factor: 4.013

2.  Purification of porcine liver pyruvate dehydrogenase complex and characterization of its catalytic and regulatory properties.

Authors:  T E Roche; R L Cate
Journal:  Arch Biochem Biophys       Date:  1977-10       Impact factor: 4.013

3.  Pyridine nucleotide distributions and enzyme mass action ratios in hepatocytes from fed and starved rats.

Authors:  M E Tischler; D Friedrichs; K Coll; J R Williamson
Journal:  Arch Biochem Biophys       Date:  1977-11       Impact factor: 4.013

4.  Feedback interactions in the control of citric acid cycle activity in rat heart mitochondria.

Authors:  K F LaNoue; J Bryla; J R Williamson
Journal:  J Biol Chem       Date:  1972-02-10       Impact factor: 5.157

5.  Kinetic and regulatory properties of heart muscle pyruvate dehydrogenase.

Authors:  O Wieland; B Von Jagow-Westermann; B Stukowski
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1969-03

6.  A linear steady-state treatment of enzymatic chains. General properties, control and effector strength.

Authors:  R Heinrich; T A Rapoport
Journal:  Eur J Biochem       Date:  1974-02-15

7.  Inhibition of muscle acetoacetate utilization during diabetic ketoacidosis.

Authors:  N B Ruderman; M N Goodman
Journal:  Am J Physiol       Date:  1974-01

8.  The control of flux.

Authors:  H Kacser; J A Burns
Journal:  Symp Soc Exp Biol       Date:  1973

9.  Effects of thyroid hormone deficiency on the distribution of hepatic metabolites and control of pathways of carbohydrate metabolism in liver and adipose tissue of the rat.

Authors:  N Z Baquer; M Cascales; P McLean; A L Greenbaum
Journal:  Eur J Biochem       Date:  1976-09-15

10.  Effect of glucagon on metabolite compartmentation in isolated rat liver cells during gluconeogenesis from lactate.

Authors:  E A Siess; D G Brocks; H K Lattke; O H Wieland
Journal:  Biochem J       Date:  1977-08-15       Impact factor: 3.857
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  3 in total

Review 1.  Metabolic control analysis: a survey of its theoretical and experimental development.

Authors:  D A Fell
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

Review 2.  Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state.

Authors:  Sean H Adams
Journal:  Adv Nutr       Date:  2011-11-03       Impact factor: 8.701

3.  An improved assay for pyruvate dehydrogenase in liver and heart.

Authors:  R Paxton; L M Sievert
Journal:  Biochem J       Date:  1991-07-15       Impact factor: 3.857
  3 in total

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