OBJECTIVE: Early expression of syndecan-1, a regulator of growth factor and chemokine function, in animal and human abortuses or placenta at delivery suggests a potential role during embryonic development. The aim of this study was to examine the correlation between early placental syndecan expression and fetal outcome in ongoing pregnancies. METHODS: Prospective immunohistochemical analysis of 203 chorionic villus sampling specimens obtained during a 4-year period (2001-2004). The chorionic villi were processed for paraffin-embedded immunohistochemistry. Scores of intensity of syndecan-1 expression in chorionic villi were correlated with maternal cofactors and pregnancy outcome. RESULTS: Syndecan-1 immunostaining was significantly related to villus size, maternal tobacco use, and fetal biometry at ultrasonography. After correcting the above confounders, scores of syndecan-1 expression correlated with preterm birth and low birth weight. CONCLUSIONS: Placental syndecan-1 expression is associated with premature birth and fetal growth.
OBJECTIVE: Early expression of syndecan-1, a regulator of growth factor and chemokine function, in animal and human abortuses or placenta at delivery suggests a potential role during embryonic development. The aim of this study was to examine the correlation between early placental syndecan expression and fetal outcome in ongoing pregnancies. METHODS: Prospective immunohistochemical analysis of 203 chorionic villus sampling specimens obtained during a 4-year period (2001-2004). The chorionic villi were processed for paraffin-embedded immunohistochemistry. Scores of intensity of syndecan-1 expression in chorionic villi were correlated with maternal cofactors and pregnancy outcome. RESULTS:Syndecan-1 immunostaining was significantly related to villus size, maternal tobacco use, and fetal biometry at ultrasonography. After correcting the above confounders, scores of syndecan-1 expression correlated with preterm birth and low birth weight. CONCLUSIONS: Placental syndecan-1 expression is associated with premature birth and fetal growth.
Authors: Sarah Jean Boeddeker; Dunja Maria Baston-Buest; Tanja Fehm; Jan Kruessel; Alexandra Hess Journal: PLoS One Date: 2015-04-01 Impact factor: 3.240
Authors: Dunja Maria Baston-Buest; Olga Altergot-Ahmad; Sarah Jean Pour; Jan-Steffen Krüssel; Udo Rudolf Markert; Tanja Natascha Fehm; Alexandra Petra Bielfeld Journal: Mediators Inflamm Date: 2017-02-15 Impact factor: 4.711
Authors: Marina Mikhaylova; Anne Schumacher; Corinna Borutzki; Janine R Neumann; Tamar Macharadze; Tarek El-Mousleh; Petra Wahle; Ana C Zenclussen; Michael R Kreutz Journal: BMC Res Notes Date: 2014-06-26