BACKGROUND: Electrical activity of the diaphragm (E(di)) has been proposed as a parameter to evaluate respiratory function. Normative values of electrical activity of the diaphragm in full-term neonates are not known. This is a small case series to establish preliminary values of E(di) in term neonates and to determine how these values vary while awake and asleep and during feeding states. METHODS: Three term neonates in room air and nippling feeds at the time of the study were observed for 4 hours. E(di) was measured by electrodes within a nasogastric tube positioned at the level of the diaphragm. Respiratory rate and heart rate were also recorded. Time while awake and asleep were noted. Feeding states included feeding, 30 min pre-prandial, and 30 min post-prandial. Statistics were analysis of variance and t tests, with P < .05. RESULTS: Mean E(di) peak was 11 ± 5 μV. Mean E(di) minimum was 3 ± 2 μV. E(di) peak and minimum were higher while awake. E(di) peak was lower post-prandial. Respiratory rate was higher post-prandial. CONCLUSIONS: These are the first preliminary values for E(di) in neonates. Higher E(di) peak while awake may reflect larger tidal volume to meet increased metabolic requirements when awake and active. Post-prandial lower E(di) peak and higher respiratory rate may indicate compensation for decreased tidal volume from increased intra-abdominal pressure. These data may be useful in identifying respiratory pathology in neonates and monitoring progression toward respiratory health. Copyright 2012 Daedalus Enterprises
BACKGROUND: Electrical activity of the diaphragm (E(di)) has been proposed as a parameter to evaluate respiratory function. Normative values of electrical activity of the diaphragm in full-term neonates are not known. This is a small case series to establish preliminary values of E(di) in term neonates and to determine how these values vary while awake and asleep and during feeding states. METHODS: Three term neonates in room air and nippling feeds at the time of the study were observed for 4 hours. E(di) was measured by electrodes within a nasogastric tube positioned at the level of the diaphragm. Respiratory rate and heart rate were also recorded. Time while awake and asleep were noted. Feeding states included feeding, 30 min pre-prandial, and 30 min post-prandial. Statistics were analysis of variance and t tests, with P < .05. RESULTS: Mean E(di) peak was 11 ± 5 μV. Mean E(di) minimum was 3 ± 2 μV. E(di) peak and minimum were higher while awake. E(di) peak was lower post-prandial. Respiratory rate was higher post-prandial. CONCLUSIONS: These are the first preliminary values for E(di) in neonates. Higher E(di) peak while awake may reflect larger tidal volume to meet increased metabolic requirements when awake and active. Post-prandial lower E(di) peak and higher respiratory rate may indicate compensation for decreased tidal volume from increased intra-abdominal pressure. These data may be useful in identifying respiratory pathology in neonates and monitoring progression toward respiratory health. Copyright 2012 Daedalus Enterprises
Authors: Jon Dorling; Oliver Hewer; Madeleine Hurd; Vasha Bari; Beth Bosiak; Ursula Bowler; Andrew King; Louise Linsell; David Murray; Omar Omar; Christopher Partlett; Catherine Rounding; John Townend; Jane Abbott; Janet Berrington; Elaine Boyle; Nicholas Embleton; Samantha Johnson; Alison Leaf; Kenny McCormick; William McGuire; Mehali Patel; Tracy Roberts; Ben Stenson; Warda Tahir; Mark Monahan; Judy Richards; Judith Rankin; Edmund Juszczak Journal: Health Technol Assess Date: 2020-04 Impact factor: 4.014