| Literature DB >> 22418279 |
Xuekui Xia1, Jianye Zhang, Yonggang Zhang, Fang Wei, Xin Liu, Airong Jia, Changheng Liu, Wei Li, Zhigang She, Yongcheng Lin.
Abstract
Three new pimarane diterpenes (1, 2 and 3) as well as a known compound 4, were isolated from the marine-derived fungus HS-1 from Apostichopus japonicus. Their structures and relative stereochemistry of 1-3 were elucidated using a combination of NMR spectroscopy and CD. In the primary bioassay, compounds 1, 2 and 4 inhibited the growth of KB and KBv200 with IC(50) of 3.51, 2.34 μg/mL, 20.74, 14.47 μg/mL, and 3.86, 6.52 μg/mL, respectively.Entities:
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Year: 2012 PMID： 22418279 DOI： 10.1016/j.bmcl.2012.01.055
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823