BACKGROUND: The influence of hepatitis C virus (HCV) infection on atherosclerosis risk in HIV-infected patients has not been adequately evaluated in real-life situations. OBJECTIVES AND METHODS: We compared indexes of early atherosclerosis evaluated by echo-Doppler ultrasound (presence of plaque in carotid or femoral arteries) in 18 HCV-HIV co-infected patients versus 22 HIV mono-infected patients. RESULTS: Prevalence of subclinical carotid plaque was significantly higher in HCV-HIV co-infected patients (p=0.04), despite of the fact LDL-cholesterol and blood pressure (BP) were lower in the co-infected patients (p=0.003). HCV chronic infection (OR=10; IC: 1.5-72; p=0.02) was an independent risk factor. CONCLUSION: This cross sectional study suggests that HCV infection might be an independent cardiovascular risk factor in HCV-HIV co-infected patients. HCV infection might be considered as not only a liver infection but also as a metabolic disease in HIV patients, justifying regular cardiovascular surveillance.
BACKGROUND: The influence of hepatitis C virus (HCV) infection on atherosclerosis risk in HIV-infectedpatients has not been adequately evaluated in real-life situations. OBJECTIVES AND METHODS: We compared indexes of early atherosclerosis evaluated by echo-Doppler ultrasound (presence of plaque in carotid or femoral arteries) in 18 HCV-HIV co-infectedpatients versus 22 HIV mono-infected patients. RESULTS: Prevalence of subclinical carotid plaque was significantly higher in HCV-HIV co-infectedpatients (p=0.04), despite of the fact LDL-cholesterol and blood pressure (BP) were lower in the co-infected patients (p=0.003). HCV chronic infection (OR=10; IC: 1.5-72; p=0.02) was an independent risk factor. CONCLUSION: This cross sectional study suggests that HCV infection might be an independent cardiovascular risk factor in HCV-HIV co-infectedpatients. HCV infection might be considered as not only a liver infection but also as a metabolic disease in HIVpatients, justifying regular cardiovascular surveillance.
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