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Literature DB >> 22415459

New verticilides, inhibitors of acyl-CoA:cholesterol acyltransferase, produced by Verticillium sp. FKI-2679.

Taichi Ohshiro¹, Daisuke Matsuda, Takeuchi Kazuhiro, Ryuji Uchida, Kenichi Nonaka, Rokuro Masuma, Hiroshi Tomoda.

Abstract

Verticillium sp. FKI-2679, a soil isolate, was found to produce inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT) in a cell-based assay using ACAT1- and ACAT2-expressing CHO cells. Three new compounds, verticilides A2, A3 and B1, were isolated along with a known compound, verticilide A1, from the fermentation broth of the fungus by solvent extraction, ODS column chromatography, silica gel column chromatography and preparative HPLC. Structure elucidation showed that these compounds were new cyclic depsipeptide. Verticilides A1, A2, A3 and B1 showed a degree of selectivity towards ACAT2, with IC(50)s 8.5-11-fold more potent than observed against ACAT1.

Entities: Chemical Gene Species

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Year: 2012 PMID： 22415459 DOI： 10.1038/ja.2012.12

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

9 in total

1. Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209.

Authors: Aika Suzuki; Takashi Fukuda; Keisuke Kobayashi; Taichi Ohshiro; Hiroshi Tomoda
Journal: J Antibiot (Tokyo) Date: 2016-05-11 Impact factor: 2.649

2. Identification of potential ACAT-2 selective inhibitors using pharmacophore, SVM and SVR from Chinese herbs.

Authors: Lian-Sheng Qiao; Xian-Bao Zhang; Lu-di Jiang; Yan-Ling Zhang; Gong-Yu Li
Journal: Mol Divers Date: 2016-06-21 Impact factor: 2.943

3. Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity.

Authors: Abigail N Smith; Daniel J Blackwell; Bjorn C Knollmann; Jeffrey N Johnston
Journal: ACS Med Chem Lett Date: 2021-11-23 Impact factor: 4.345

4. Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072.

Authors: Keisuke Kobayashi; Takashi Fukuda; Takeo Usui; Yuko Kurihara; Akihiko Kanamoto; Hiroshi Tomoda
Journal: J Antibiot (Tokyo) Date: 2014-08-06 Impact factor: 2.649

New verticilides, inhibitors of acyl-CoA:cholesterol acyltransferase, produced by Verticillium sp. FKI-2679.

1. Pseudopyronine B, an inhibitor of sterol O-acyltransferase, produced by Pseudomonas sp. BYK11209.

2. Identification of potential ACAT-2 selective inhibitors using pharmacophore, SVM and SVR from Chinese herbs.

3. Ring Size as an Independent Variable in Cyclooligomeric Depsipeptide Antiarrhythmic Activity.

4. Bafilomycin L, a new inhibitor of cholesteryl ester synthesis in mammalian cells, produced by marine-derived Streptomyces sp. OPMA00072.

5. Aspersymmetide A, a New Centrosymmetric Cyclohexapeptide from the Marine-Derived Fungus Aspergillus versicolor.

6. Cyclic Octamer Peptoids: Simplified Isosters of Bioactive Fungal Cyclodepsipeptides.

Review 7. Risks of Mycotoxins from Mycoinsecticides to Humans.

8. A Mixture of Atropisomers Enhances Neutral Lipid Degradation in Mammalian Cells with Autophagy Induction.

Review 9. Structural Diversity and Biological Activities of Cyclic Depsipeptides from Fungi.