N-(2-Hy-droxy-eth-yl)-5-(4-meth-oxy-phen-yl)-4H-pyrazole-3-carboxamide.

In the title compound, C(13)H(15)N(3)O(3), the dihedral angle between the benzene and pyrazole rings is 7.7 (1)° and the O-C-C-N torsion angle of the side chain is 74.1 (2)°. In the crystal, mol-ecules are linked by O-H⋯O, N-H⋯O and N-H⋯N hydrogen bonds.

Related literature

For the biological activities of pyrazole derivatives, see: Qi et al. (2011 ▶). For a related structure, see: Shi & Xie (2011 ▶).

Experimental

Crystal data

C13H15N3O3

M = 261.28

Monoclinic,

a = 21.82 (5) Å

b = 10.08 (2) Å

c = 12.28 (3) Å

β = 110.53 (3)°

V = 2531 (11) Å3

Z = 8

Mo Kα radiation

μ = 0.10 mm−1

T = 293 K

0.20 × 0.15 × 0.06 mm

Data collection

Bruker SMART CCD diffractometer

Absorption correction: multi-scan (SADABS; Bruker, 2000 ▶) T min = 0.980, T max = 0.994

5292 measured reflections

2366 independent reflections

1841 reflections with I > 2σ(I)

R int = 0.074

Refinement

R[F 2 > 2σ(F 2)] = 0.054

wR(F 2) = 0.156

S = 1.05

2366 reflections

175 parameters

H-atom parameters constrained

Δρmax = 0.26 e Å−3

Δρmin = −0.30 e Å−3

Data collection: SMART (Bruker, 2000 ▶); cell refinement: SAINT (Bruker, 2000 ▶); data reduction: SAINT; program(s) used to solve structure: SHELXS97 (Sheldrick, 2008 ▶); program(s) used to refine structure: SHELXL97 (Sheldrick, 2008 ▶); molecular graphics: SHELXTL (Sheldrick, 2008 ▶); software used to prepare material for publication: SHELXTL.

Crystal structure: contains datablock(s) I, global. DOI: 10.1107/S1600536812007829/hb6641sup1.cif

Structure factors: contains datablock(s) I. DOI: 10.1107/S1600536812007829/hb6641Isup2.hkl

Supplementary material file. DOI: 10.1107/S1600536812007829/hb6641Isup3.cdx

Supplementary material file. DOI: 10.1107/S1600536812007829/hb6641Isup4.cml

Additional supplementary materials: crystallographic information; 3D view; checkCIF report

C13H15N3O3	Dx = 1.372 Mg m−3
Mr = 261.28	Melting point: 470 K
Monoclinic, C2/c	Mo Kα radiation, λ = 0.71073 Å
a = 21.82 (5) Å	Cell parameters from 925 reflections
b = 10.08 (2) Å	θ = 3.1–26.4°
c = 12.28 (3) Å	µ = 0.10 mm−1
β = 110.53 (3)°	T = 293 K
V = 2531 (11) Å3	Slab, colorless
Z = 8	0.20 × 0.15 × 0.06 mm
F(000) = 1104

Bruker SMART CCD diffractometer	2366 independent reflections
Radiation source: fine-focus sealed tube	1841 reflections with I > 2σ(I)
Graphite monochromator	Rint = 0.074
phi and ω scans	θmax = 25.5°, θmin = 2.0°
Absorption correction: multi-scan (SADABS; Bruker, 2000)	h = −26→10
Tmin = 0.980, Tmax = 0.994	k = −12→12
5292 measured reflections	l = −13→14

Refinement on F2	Secondary atom site location: difference Fourier map
Least-squares matrix: full	Hydrogen site location: inferred from neighbouring sites
R[F2 > 2σ(F2)] = 0.054	H-atom parameters constrained
wR(F2) = 0.156	w = 1/[σ2(Fo2) + (0.0917P)2 + 0.0958P] whereP = (Fo2 + 2Fc2)/3
S = 1.05	(Δ/σ)max < 0.001
2366 reflections	Δρmax = 0.26 e Å−3
175 parameters	Δρmin = −0.30 e Å−3
0 restraints	Extinction correction: SHELXL97 (Sheldrick, 2008), Fc*=kFc[1+0.001xFc2λ3/sin(2θ)]-1/4
Primary atom site location: structure-invariant direct methods	Extinction coefficient: 0.0026 (8)

Geometry. All e.s.d.'s (except the e.s.d. in the dihedral angle between two l.s. planes) are estimated using the full covariance matrix. The cell e.s.d.'s are taken into account individually in the estimation of e.s.d.'s in distances, angles and torsion angles; correlations between e.s.d.'s in cell parameters are only used when they are defined by crystal symmetry. An approximate (isotropic) treatment of cell e.s.d.'s is used for estimating e.s.d.'s involving l.s. planes.

Refinement. Refinement of F2 against ALL reflections. The weighted R-factor wR and goodness of fit S are based on F2, conventional R-factors R are based on F, with F set to zero for negative F2. The threshold expression of F2 > σ(F2) is used only for calculating R-factors(gt) etc. and is not relevant to the choice of reflections for refinement. R-factors based on F2 are statistically about twice as large as those based on F, and R- factors based on ALL data will be even larger.

	x	y	z	Uiso*/Ueq
N1	0.29642 (7)	0.24543 (15)	0.29533 (13)	0.0426 (4)
H1D	0.3331	0.2866	0.3241	0.051*
N2	0.25083 (7)	0.24377 (15)	0.34610 (13)	0.0433 (4)
N3	0.13697 (7)	0.21072 (15)	0.39238 (13)	0.0414 (4)
H3B	0.1720	0.2410	0.4441	0.050*
O1	0.44500 (7)	0.12084 (15)	−0.06540 (14)	0.0593 (5)
O2	0.09398 (6)	0.09459 (14)	0.22772 (11)	0.0526 (4)
O3	0.09522 (7)	0.10663 (15)	0.58747 (12)	0.0575 (4)
H3	0.0904	0.0361	0.6168	0.086*
C1	0.42987 (12)	0.0298 (2)	−0.15960 (19)	0.0621 (6)
H1A	0.4244	−0.0573	−0.1329	0.093*
H1B	0.4649	0.0286	−0.1898	0.093*
H1C	0.3901	0.0567	−0.2197	0.093*
C2	0.40166 (9)	0.13059 (18)	−0.00812 (17)	0.0435 (5)
C3	0.34387 (9)	0.06118 (19)	−0.03558 (17)	0.0470 (5)
H3A	0.3312	0.0034	−0.0986	0.056*
C4	0.30463 (9)	0.0776 (2)	0.03073 (18)	0.0455 (5)
H4	0.2660	0.0292	0.0120	0.055*
C5	0.32117 (8)	0.16408 (18)	0.12430 (15)	0.0387 (4)
C6	0.37895 (10)	0.23460 (19)	0.14879 (18)	0.0481 (5)
H6	0.3909	0.2949	0.2100	0.058*
C7	0.41911 (10)	0.2177 (2)	0.08479 (19)	0.0512 (6)
H7	0.4581	0.2649	0.1041	0.061*
C8	0.27897 (9)	0.17627 (17)	0.19481 (15)	0.0382 (4)
C9	0.21809 (9)	0.12518 (19)	0.17982 (16)	0.0416 (5)
H9	0.1924	0.0720	0.1192	0.050*
C10	0.20311 (8)	0.17037 (18)	0.27537 (16)	0.0386 (4)
C11	0.14091 (8)	0.15331 (17)	0.29704 (15)	0.0377 (4)
C12	0.07505 (9)	0.22326 (18)	0.41093 (16)	0.0400 (5)
H12A	0.0407	0.2374	0.3362	0.048*
H12B	0.0769	0.3015	0.4579	0.048*
C13	0.05641 (9)	0.10679 (19)	0.46890 (16)	0.0426 (5)
H13A	0.0105	0.1126	0.4600	0.051*
H13B	0.0630	0.0250	0.4329	0.051*

	U11	U22	U33	U12	U13	U23
N1	0.0394 (8)	0.0550 (10)	0.0340 (9)	−0.0095 (7)	0.0135 (7)	−0.0065 (7)
N2	0.0441 (9)	0.0540 (10)	0.0343 (9)	−0.0066 (7)	0.0169 (7)	−0.0064 (7)
N3	0.0376 (8)	0.0561 (10)	0.0301 (8)	−0.0080 (7)	0.0114 (7)	−0.0086 (7)
O1	0.0660 (10)	0.0645 (10)	0.0627 (10)	−0.0145 (7)	0.0417 (9)	−0.0168 (7)
O2	0.0388 (8)	0.0742 (10)	0.0420 (8)	−0.0095 (6)	0.0107 (6)	−0.0206 (7)
O3	0.0585 (9)	0.0622 (10)	0.0378 (8)	−0.0229 (7)	−0.0006 (7)	0.0077 (6)
C1	0.0806 (16)	0.0644 (14)	0.0562 (14)	−0.0077 (12)	0.0429 (13)	−0.0116 (11)
C2	0.0514 (11)	0.0425 (10)	0.0417 (11)	−0.0008 (8)	0.0229 (9)	0.0007 (8)
C3	0.0550 (12)	0.0480 (11)	0.0410 (11)	−0.0055 (9)	0.0205 (10)	−0.0091 (9)
C4	0.0432 (10)	0.0507 (11)	0.0427 (11)	−0.0080 (8)	0.0152 (9)	−0.0054 (9)
C5	0.0413 (10)	0.0416 (10)	0.0336 (10)	0.0009 (8)	0.0134 (8)	0.0027 (8)
C6	0.0537 (12)	0.0507 (11)	0.0441 (11)	−0.0116 (9)	0.0225 (10)	−0.0121 (9)
C7	0.0520 (12)	0.0549 (12)	0.0527 (13)	−0.0147 (9)	0.0257 (10)	−0.0094 (10)
C8	0.0418 (10)	0.0413 (9)	0.0301 (10)	−0.0004 (8)	0.0108 (8)	−0.0003 (7)
C9	0.0403 (10)	0.0514 (11)	0.0318 (10)	−0.0060 (8)	0.0110 (8)	−0.0068 (8)
C10	0.0367 (9)	0.0458 (10)	0.0320 (9)	−0.0017 (7)	0.0102 (8)	−0.0015 (8)
C11	0.0379 (10)	0.0443 (10)	0.0298 (9)	−0.0006 (8)	0.0106 (8)	−0.0013 (7)
C12	0.0388 (10)	0.0486 (11)	0.0320 (10)	0.0018 (8)	0.0118 (8)	−0.0009 (8)
C13	0.0390 (10)	0.0499 (11)	0.0355 (10)	−0.0082 (8)	0.0087 (8)	−0.0044 (8)

N1—N2	1.347 (3)	C3—H3A	0.9300
N1—C8	1.351 (3)	C4—C5	1.386 (4)
N1—H1D	0.8600	C4—H4	0.9300
N2—C10	1.324 (3)	C5—C6	1.385 (4)
N3—C11	1.336 (4)	C5—C8	1.474 (3)
N3—C12	1.452 (4)	C6—C7	1.378 (4)
N3—H3B	0.8600	C6—H6	0.9300
O1—C2	1.366 (3)	C7—H7	0.9300
O1—C1	1.422 (4)	C8—C9	1.376 (4)
O2—C11	1.230 (3)	C9—C10	1.400 (4)
O3—C13	1.405 (4)	C9—H9	0.9300
O3—H3	0.8200	C10—C11	1.482 (4)
C1—H1A	0.9600	C12—C13	1.502 (4)
C1—H1B	0.9600	C12—H12A	0.9700
C1—H1C	0.9600	C12—H12B	0.9700
C2—C3	1.377 (4)	C13—H13A	0.9700
C2—C7	1.383 (4)	C13—H13B	0.9700
C3—C4	1.383 (3)
N2—N1—C8	113.55 (19)	C5—C6—H6	119.2
N2—N1—H1D	123.2	C6—C7—C2	120.2 (2)
C8—N1—H1D	123.2	C6—C7—H7	119.9
C10—N2—N1	104.0 (2)	C2—C7—H7	119.9
C11—N3—C12	121.65 (15)	N1—C8—C9	105.35 (16)
C11—N3—H3B	119.2	N1—C8—C5	123.1 (2)
C12—N3—H3B	119.2	C9—C8—C5	131.5 (2)
C2—O1—C1	117.42 (19)	C8—C9—C10	105.33 (19)
C13—O3—H3	109.5	C8—C9—H9	127.3
O1—C1—H1A	109.5	C10—C9—H9	127.3
O1—C1—H1B	109.5	N2—C10—C9	111.8 (2)
H1A—C1—H1B	109.5	N2—C10—C11	120.4 (2)
O1—C1—H1C	109.5	C9—C10—C11	127.62 (17)
H1A—C1—H1C	109.5	O2—C11—N3	121.4 (2)
H1B—C1—H1C	109.5	O2—C11—C10	121.6 (2)
O1—C2—C3	125.3 (2)	N3—C11—C10	116.86 (16)
O1—C2—C7	115.5 (2)	N3—C12—C13	115.33 (17)
C3—C2—C7	119.21 (18)	N3—C12—H12A	108.4
C2—C3—C4	119.9 (2)	C13—C12—H12A	108.4
C2—C3—H3A	120.1	N3—C12—H12B	108.4
C4—C3—H3A	120.1	C13—C12—H12B	108.4
C3—C4—C5	121.9 (2)	H12A—C12—H12B	107.5
C3—C4—H4	119.0	O3—C13—C12	109.12 (19)
C5—C4—H4	119.0	O3—C13—H13A	109.9
C6—C5—C4	117.09 (18)	C12—C13—H13A	109.9
C6—C5—C8	122.5 (2)	O3—C13—H13B	109.9
C4—C5—C8	120.3 (2)	C12—C13—H13B	109.9
C7—C6—C5	121.7 (2)	H13A—C13—H13B	108.3
C7—C6—H6	119.2

D—H···A	D—H	H···A	D···A	D—H···A
O3—H3···O2i	0.82	1.88	2.668 (5)	162
N3—H3B···N2ii	0.86	2.54	3.318 (7)	151
N1—H1D···O3ii	0.86	1.90	2.739 (5)	166

Table 1

Hydrogen-bond geometry (Å, °)

D—H⋯A	D—H	H⋯A	D⋯A	D—H⋯A
O3—H3⋯O2i	0.82	1.88	2.668 (5)	162
N3—H3B⋯N2ii	0.86	2.54	3.318 (7)	151
N1—H1D⋯O3ii	0.86	1.90	2.739 (5)	166

Symmetry codes: (i) ; (ii) .