Literature DB >> 22412234

Metastatic carcinoid disease inducing coronary vasospasm.

Danny J Eapen1, Stephen Clements, Peter Block, Laurence Sperling.   

Abstract

Herein, we report a case of progressive coronary vasospasm in a 70-year-old man who had a long-standing history of metastatic gastrointestinal carcinoid tumor. Despite octreotide, nitrate, and calcium channel-blocker therapy, the patient's urinary 5-hydroxy-indole acetic acid level increased, coinciding with an increased frequency of flushing episodes with chest discomfort. In the cardiac catheterization laboratory, we captured an episode that was associated with diffuse right coronary artery spasm, ST-segment elevation, and intense symptoms. We attribute the patient's coronary vasospasm to his metastatic carcinoid disease.

Entities:  

Keywords:  Angina pectoris, variant/drug therapy; coronary disease/physiopathology; coronary vasospasm/diagnosis/etiology/physiopathology; flushing/etiology; malignant carcinoid syndrome/complications; octreotide/administration & dosage; treatment outcome

Mesh:

Substances:

Year:  2012        PMID: 22412234      PMCID: PMC3298897     

Source DB:  PubMed          Journal:  Tex Heart Inst J        ISSN: 0730-2347


  9 in total

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Journal:  Lancet       Date:  1966-06-04       Impact factor: 79.321

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Journal:  Ann Intern Med       Date:  1994-07-15       Impact factor: 25.391

3.  Evidence for coronary spasm during flushing in the carcinoid syndrome.

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Journal:  Clin Cardiol       Date:  1984-08       Impact factor: 2.882

Review 4.  Platelet-derived serotonin, the endothelium, and cardiovascular disease.

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Journal:  J Cardiovasc Pharmacol       Date:  1991       Impact factor: 3.105

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Journal:  Cardiovasc Res       Date:  1990-11       Impact factor: 10.787

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Authors:  M Muszkat; M Shalit; C Lotan; A Ben-Yehuda
Journal:  J Intern Med       Date:  2000-02       Impact factor: 8.989

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Journal:  Am J Med       Date:  1959-09       Impact factor: 4.965

8.  The vasoactive effect of serotonin on canine coronary arteries after ischemia and reperfusion.

Authors:  F M Sheridan
Journal:  Coron Artery Dis       Date:  1994-06       Impact factor: 1.439

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Authors:  E J Topol; N J Fortuin
Journal:  Am J Med       Date:  1984-11       Impact factor: 4.965

  9 in total
  4 in total

1.  Treating coronary vasospasm and tumor burden medically.

Authors:  James A York
Journal:  Tex Heart Inst J       Date:  2012

Review 2.  Carcinoid Heart Disease: Review of Current Knowledge.

Authors:  Pradhum Ram; Jorge L Penalver; Kevin Bryan U Lo; Janani Rangaswami; Gregg S Pressman
Journal:  Tex Heart Inst J       Date:  2019-02-01

Review 3.  Carcinoid Heart Disease: a Comprehensive Review.

Authors:  Saamir A Hassan; Nicolas L Palaskas; Ali M Agha; Cezar Iliescu; Juan Lopez-Mattei; Christopher Chen; Henry Zheng; Syed Wamique Yusuf
Journal:  Curr Cardiol Rep       Date:  2019-11-19       Impact factor: 2.931

4.  Carcinoid Syndrome-Induced Ventricular Tachycardia.

Authors:  Austin B Rupp; Abdulmohsin Ahmadjee; Jack H Morshedzadeh; Ravi Ranjan
Journal:  Case Rep Cardiol       Date:  2016-03-21
  4 in total

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