Literature DB >> 22411689

Oral supplementation with dihomo-γ-linolenic acid (DGLA)-enriched oil increases serum DGLA content in healthy adults.

Takao Tanaka1, Saki Kakutani, Chika Horikawa, Hiroshi Kawashima, Yoshinobu Kiso.   

Abstract

Dihomo-γ-linolenic acid (DGLA) is one of the polyunsaturated fatty acids, and is expected to show anti-allergic activity. We examined the effects of supplementation with DGLA-enriched oil (450 mg as free DGLA) for 4 weeks in healthy adults in a randomized controlled study. The DGLA composition in the total fatty acids of serum phospholipids increased from 2.0 to 3.4%, and returned to the initial level after a 4-week washout. No side effects or changes in blood biochemical parameters were observed. These results indicate that serum DGLA content can be safely increased by supplementation with 450 mg DGLA under these conditions.

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Year:  2012        PMID： 22411689     DOI： 10.1007/s11745-012-3664-3

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  11 in total

1.  A simple method for the isolation and purification of total lipides from animal tissues.

Authors:  J FOLCH; M LEES; G H SLOANE STANLEY
Journal:  J Biol Chem       Date:  1957-05       Impact factor: 5.157

2.  Delta 9-fatty acid desaturase from arachidonic acid-producing fungus. Unique gene sequence and its heterologous expression in a fungus, Aspergillus.

Authors:  E Sakuradani; M Kobayashi; S Shimizu
Journal:  Eur J Biochem       Date:  1999-02

3.  Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema.

Authors:  B M Henz; S Jablonska; P C van de Kerkhof; G Stingl; M Blaszczyk; P G Vandervalk; R Veenhuizen; R Muggli; D Raederstorff
Journal:  Br J Dermatol       Date:  1999-04       Impact factor: 9.302

4.  Oral administration of dihomo-gamma-linolenic acid prevents development of atopic dermatitis in NC/Nga mice.

Authors:  H Kawashima; N Tateishi; A Shiraishi; N Teraoka; T Tanaka; A Tanaka; H Matsuda; Y Kiso
Journal:  Lipids       Date:  2007-11-06       Impact factor: 1.880

5.  The modulatory effects of prostaglandin-E on cytokine production by human peripheral blood mononuclear cells are independent of the prostaglandin subtype.

Authors:  Maaike M B W Dooper; Lianne Wassink; Laura M'Rabet; Yvo M F Graus
Journal:  Immunology       Date:  2002-09       Impact factor: 7.397

6.  Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.

Authors:  Shinji Takai; Denan Jin; Hiroshi Kawashima; Maki Kimura; Akiko Shiraishi-Tateishi; Takao Tanaka; Saki Kakutani; Kazuhiko Tanaka; Yoshinobu Kiso; Mizuo Miyazaki
Journal:  J Atheroscler Thromb       Date:  2009-08-27       Impact factor: 4.928

7.  Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins.

Authors:  M Schalin-Karrila; L Mattila; C T Jansen; P Uotila
Journal:  Br J Dermatol       Date:  1987-07       Impact factor: 9.302

8.  Effect of dihomogammalinolenic acid and its 15-lipoxygenase metabolite on eicosanoid metabolism by human mononuclear leukocytes in vitro: selective inhibition of the 5-lipoxygenase pathway.

Authors:  L Iversen; K Fogh; K Kragballe
Journal:  Arch Dermatol Res       Date:  1992       Impact factor: 3.017

9.  Reduced levels of prostaglandin precursors in the blood of atopic patients: defective delta-6-desaturase function as a biochemical basis for atopy.

Authors:  M S Manku; D F Horrobin; N Morse; V Kyte; K Jenkins; S Wright; J L Burton
Journal:  Prostaglandins Leukot Med       Date:  1982-12

10.  Oral supplementation with dihomo-gamma-linolenic acid-enriched oil altered serum fatty acids in healthy men.

Authors:  Naoya Teraoka; Hiroshi Kawashima; Akiko Shiraishi-Tateishi; Takao Tanaka; Junichi Nakamura; Saki Kakutani; Yoshinobu Kiso
Journal:  Biosci Biotechnol Biochem       Date:  2009-06-07       Impact factor: 2.043
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  2 in total

1.  Serum fatty acids and progression from dengue fever to dengue haemorrhagic fever/dengue shock syndrome.

Authors:  Eduardo Villamor; Luis A Villar; Anyela Lozano-Parra; Víctor M Herrera; Oscar F Herrán
Journal:  Br J Nutr       Date:  2018-08-14       Impact factor: 3.718

2.  Dihomo-γ-linolenic acid inhibits several key cellular processes associated with atherosclerosis.

Authors:  Hayley Gallagher; Jessica O Williams; Nele Ferekidis; Alaa Ismail; Yee-Hung Chan; Daryn R Michael; Irina A Guschina; Victoria J Tyrrell; Valerie B O'Donnell; John L Harwood; Inna Khozin-Goldberg; Sammy Boussiba; Dipak P Ramji
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2019-06-13       Impact factor: 5.187
  2 in total

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