| Literature DB >> 22411269 |
K L Kolho1, D Turner, G Veereman-Wauters, M Sladek, L de Ridder, R Shaoul, A Paerregaard, J Amil Dias, S Koletzko, F Nuti, Y Bujanover, A Staiano, K Bochenek, L Finnby, A Levine, G Veres.
Abstract
Assessment of fecal calprotectin, a surrogate marker of mucosal inflammation, is a promising means to monitor therapeutic response in pediatric inflammatory bowel disease, especially if the result is readily available. We tested the performance of a novel calprotectin rapid test, Quantum Blue, versus the conventional enzyme-linked immunosorbent assay in 134 stool samples from 56 pediatric patients with Crohn disease. The intraclass correlation coefficient analysis reflected good agreement (intraclass correlation coefficient 0.97 [95% confidence interval 0.95-0.98]) but agreement was better in lower values, where dilutions were not required. Using a cutoff of 100 μg/g for normal values, the percentage agreement between the 2 tests was 87%. The optimal cutoff values to guide clinical decisions in the therapy of inflammatory bowel disease have yet to be determined.Entities:
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Year: 2012 PMID： 22411269 DOI： 10.1097/MPG.0b013e318253cff1
Source DB: PubMed Journal: J Pediatr Gastroenterol Nutr ISSN： 0277-2116 Impact factor: 2.839