AIM: Cholecystectomy has been suggested as a risk factor for colorectal cancer. However, the association of cholecystectomy and the risk of colorectal adenoma (CRA) remains unclear. We conducted a meta-analysis of observational studies to explore this relationship. METHODS: We identified studies by a literature search of MEDLINE and EMBASE through 30 September 2011, and by searching the reference lists of pertinent articles. Summary relative risks (SRRs) with their 95% confidence intervals (CIs) were calculated with a random-effects model. Between-study heterogeneity was assessed using Cochran's Q statistic and the I2. RESULTS: A total of 10 studies (including 4061 CRA cases) were included in this meta-analysis. Analysis of these 10 studies found that no effect of cholecystectomy on the risk of CRAs was shown (SRR, 1.17; 95% CI: 0.93-1.48), with no significant heterogeneity among these studies (P heterogeneity=0.106, I2=37.9%). This null association was seen in both men and women (men: SRR=1.00, 95% CI: 0.58-1.73; women: SRR=1.39, 95% CI: 0.95-2.04). CONCLUSION: The results of this meta-analysis suggest that there is no positive association between previous cholecystectomy and the risk of CRA development in both men and women.
AIM: Cholecystectomy has been suggested as a risk factor for colorectal cancer. However, the association of cholecystectomy and the risk of colorectal adenoma (CRA) remains unclear. We conducted a meta-analysis of observational studies to explore this relationship. METHODS: We identified studies by a literature search of MEDLINE and EMBASE through 30 September 2011, and by searching the reference lists of pertinent articles. Summary relative risks (SRRs) with their 95% confidence intervals (CIs) were calculated with a random-effects model. Between-study heterogeneity was assessed using Cochran's Q statistic and the I2. RESULTS: A total of 10 studies (including 4061 CRA cases) were included in this meta-analysis. Analysis of these 10 studies found that no effect of cholecystectomy on the risk of CRAs was shown (SRR, 1.17; 95% CI: 0.93-1.48), with no significant heterogeneity among these studies (P heterogeneity=0.106, I2=37.9%). This null association was seen in both men and women (men: SRR=1.00, 95% CI: 0.58-1.73; women: SRR=1.39, 95% CI: 0.95-2.04). CONCLUSION: The results of this meta-analysis suggest that there is no positive association between previous cholecystectomy and the risk of CRA development in both men and women.
Authors: Tomasz Sawicki; Monika Ruszkowska; Anna Danielewicz; Ewa Niedźwiedzka; Tomasz Arłukowicz; Katarzyna E Przybyłowicz Journal: Cancers (Basel) Date: 2021-04-22 Impact factor: 6.639
Authors: Jie Shang; Jeanette C Reece; Daniel D Buchanan; Graham G Giles; Jane C Figueiredo; Graham Casey; Steven Gallinger; Stephen N Thibodeau; Noralane M Lindor; Polly A Newcomb; John D Potter; John A Baron; John L Hopper; Mark A Jenkins; Aung Ko Win Journal: Int J Colorectal Dis Date: 2016-06-10 Impact factor: 2.796