| Literature DB >> 22409456 |
Shi Chen1, Eric C Salo, Kraig A Wheeler, Nessan J Kerrigan.
Abstract
The development of a BINAPHANE-catalyzed formal [2 + 2]-cycloaddition of disubstituted ketenes and inexpensive N-tosyl arylimines that provides access to a variety of highly substituted β-lactams (16 examples) is described. The BINAPHANE catalytic system displays moderate to excellent enantioselectivity (up to 98% ee) and high diastereoselectivity in most cases, favoring formation of the trans-diastereomer (13 examples with dr ≥ 90:10).Entities:
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Year: 2012 PMID： 22409456 DOI： 10.1021/ol3003783
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005