| Literature DB >> 22408642 |
Frank Emmert-Streib1, Galina V Glazko, Gökmen Altay, Ricardo de Matos Simoes.
Abstract
In this paper, we present a systematic and conceptual overview of methods for inferring gene regulatory networks from observational gene expression data. Further, we discuss two classic approaches to infer causal structures and compare them with contemporary methods by providing a conceptual categorization thereof. We complement the above by surveying global and local evaluation measures for assessing the performance of inference algorithms.Entities:
Keywords: Bayesian network; causal relations; directed acyclic graphs; gene regulatory networks; information-theory methods; reverse engineering; statistical inference
Year: 2012 PMID: 22408642 PMCID: PMC3271232 DOI: 10.3389/fgene.2012.00008
Source DB: PubMed Journal: Front Genet ISSN: 1664-8021 Impact factor: 4.599