Literature DB >> 22406000

Renal cancer: oxygen meets metabolism.

Volker H Haase1.   

Abstract

Over the last two decades molecular studies of inherited tumor syndromes that are associated with the development of kidney cancer have led to the identification of genes and biochemical pathways, which play key roles in the malignant transformation of renal epithelial cells. Some of these findings have broad biological impact and extend beyond renal cancer. This review's focus is on the von Hippel-Lindau (VHL)/hypoxia-inducible factor (HIF) oxygen-sensing pathway and its role in physiology, energy metabolism and tumorigenesis.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22406000      PMCID： PMC3334413          DOI： 10.1016/j.yexcr.2012.02.026

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  108 in total

1.  The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Authors:  P H Maxwell; M S Wiesener; G W Chang; S C Clifford; E C Vaux; M E Cockman; C C Wykoff; C W Pugh; E R Maher; P J Ratcliffe
Journal:  Nature       Date:  1999-05-20       Impact factor: 49.962

2.  The von Hippel-Lindau tumor suppressor gene product represses oncogenic beta-catenin signaling in renal carcinoma cells.

Authors:  Benedetta Peruzzi; Gagani Athauda; Donald P Bottaro
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-18       Impact factor: 11.205

3.  Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

Authors:  Matthew G Vander Heiden; Jason W Locasale; Kenneth D Swanson; Hadar Sharfi; Greg J Heffron; Daniel Amador-Noguez; Heather R Christofk; Gerhard Wagner; Joshua D Rabinowitz; John M Asara; Lewis C Cantley
Journal:  Science       Date:  2010-09-17       Impact factor: 47.728

4.  Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

Authors:  Miguel A Esteban; Maxine G B Tran; Sarah K Harten; Peter Hill; Maria C Castellanos; Ashish Chandra; Raju Raval; Tim S O'brien; Patrick H Maxwell
Journal:  Cancer Res       Date:  2006-04-01       Impact factor: 12.701

Review 5.  von Hippel-Lindau disease.

Authors:  Russell R Lonser; Gladys M Glenn; McClellan Walther; Emily Y Chew; Steven K Libutti; W Marston Linehan; Edward H Oldfield
Journal:  Lancet       Date:  2003-06-14       Impact factor: 79.321

6.  Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

Authors:  Ineke P Stolze; Ya-Min Tian; Rebecca J Appelhoff; Helen Turley; Charles C Wykoff; Jonathan M Gleadle; Peter J Ratcliffe
Journal:  J Biol Chem       Date:  2004-08-09       Impact factor: 5.157

7.  HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma.

Authors:  John D Gordan; Priti Lal; Vijay R Dondeti; Richard Letrero; Krishna N Parekh; C Elisa Oquendo; Roger A Greenberg; Keith T Flaherty; W Kimryn Rathmell; Brian Keith; M Celeste Simon; Katherine L Nathanson
Journal:  Cancer Cell       Date:  2008-12-09       Impact factor: 31.743

8.  Regulation of endocytosis via the oxygen-sensing pathway.

Authors:  Yi Wang; Olga Roche; Mathew S Yan; Greg Finak; Andrew J Evans; Julie L Metcalf; Bridgid E Hast; Sara C Hanna; Bill Wondergem; Kyle A Furge; Meredith S Irwin; William Y Kim; Bin T Teh; Sergio Grinstein; Morag Park; Philip A Marsden; Michael Ohh
Journal:  Nat Med       Date:  2009-03-01       Impact factor: 53.440

9.  Inactivation of BHD in sporadic renal tumors.

Authors:  Sok Kean Khoo; Katherine Kahnoski; Jun Sugimura; David Petillo; Jindong Chen; Ken Shockley; John Ludlow; Robert Knapp; Sophie Giraud; Stéphane Richard; Magnus Nordenskjöld; Bin Tean Teh
Journal:  Cancer Res       Date:  2003-08-01       Impact factor: 12.701

10.  Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.

Authors:  Michael Zimmer; Darrell Doucette; Naila Siddiqui; Othon Iliopoulos
Journal:  Mol Cancer Res       Date:  2004-02       Impact factor: 5.852
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  18 in total

Review 1.  Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential.

Authors:  Ming Pei
Journal:  Biomaterials       Date:  2016-11-25       Impact factor: 12.479

Review 2.  TRP channels as sensors of oxygen availability.

Authors:  Tomohiro Numata; Nozomi Ogawa; Nobuaki Takahashi; Yasuo Mori
Journal:  Pflugers Arch       Date:  2013-02-17       Impact factor: 3.657

Review 3.  Therapeutic targeting of the HIF oxygen-sensing pathway: Lessons learned from clinical studies.

Authors:  Volker H Haase
Journal:  Exp Cell Res       Date:  2017-05-05       Impact factor: 3.905

4.  Rotenone Stereospecifically Increases (S)-2-Hydroxyglutarate in SH-SY5Y Neuronal Cells.

Authors:  Andrew J Worth; Kevin P Gillespie; Clementina Mesaros; Lili Guo; Sankha S Basu; Nathaniel W Snyder; Ian A Blair
Journal:  Chem Res Toxicol       Date:  2015-04-08       Impact factor: 3.739

5.  β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma.

Authors:  Ruhee Dere; Ashley Lyn Perkins; Tasneem Bawa-Khalfe; Darius Jonasch; Cheryl Lyn Walker
Journal:  J Am Soc Nephrol       Date:  2014-10-13       Impact factor: 10.121

6.  Patterns of Expression of H2S-Producing Enzyme in Human Renal Cell Carcinoma Specimens: Potential Avenue for Future Therapeutics.

Authors:  Emrullah Sogutdelen; Katharine Pacoli; Smriti Juriasingani; Masoud Akbari; Manal Gabril; Alp Sener
Journal:  In Vivo       Date:  2020 Sep-Oct       Impact factor: 2.155

Review 7.  HIF-prolyl hydroxylases as therapeutic targets in erythropoiesis and iron metabolism.

Authors:  Volker H Haase
Journal:  Hemodial Int       Date:  2017-06       Impact factor: 1.812

8.  (-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.

Authors:  Yasemin Akbulut; Hannah J Gaunt; Katsuhiko Muraki; Melanie J Ludlow; Mohamed S Amer; Alexander Bruns; Naveen S Vasudev; Lea Radtke; Matthieu Willot; Sven Hahn; Tobias Seitz; Slava Ziegler; Mathias Christmann; David J Beech; Herbert Waldmann
Journal:  Angew Chem Int Ed Engl       Date:  2015-02-23       Impact factor: 15.336

9.  TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss.

Authors:  Lianxin Hu; Haibiao Xie; Xijuan Liu; Frances Potjewyd; Lindsey I James; Emily M Wilkerson; Laura E Herring; Ling Xie; Xian Chen; Johnny Castillo Cabrera; Kai Hong; Chengheng Liao; Xianming Tan; Albert S Baldwin; Kan Gong; Qing Zhang
Journal:  Cancer Discov       Date:  2019-12-06       Impact factor: 38.272

10.  Renal cancer-selective Englerin A induces multiple mechanisms of cell death and autophagy.

Authors:  Richard T Williams; Alice L Yu; Mitchell B Diccianni; Emmanuel A Theodorakis; Ayse Batova
Journal:  J Exp Clin Cancer Res       Date:  2013-08-20
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