Daniel Nelson1, Rees Porta1, Kelly Blair1, Preston Carter1, Matthew Martin2. 1. Department of Surgery, Madigan Army Medical Center, 9040-A Fitzsimmons Ave., Tacoma, WA 98431, USA. 2. Department of Surgery, Madigan Army Medical Center, 9040-A Fitzsimmons Ave., Tacoma, WA 98431, USA. Electronic address: matthew.martin1@us.army.mil.
Abstract
BACKGROUND: Obesity is associated with cardiovascular risk factors such as lipid levels and increased levels of C-reactive peptide (CRP). We hypothesized that duodenal switch (DS) would show equivalent or superior risk reduction compared with standard bariatric surgeries. METHODS: Patients underwent DS, sleeve gastrectomy (SG), or gastric bypass (GB) over a 2-year period. Body mass index (BMI), lipid panel, and CRP were measured preoperatively and then 3, 6, and 12 months postoperatively. RESULTS: A total of 130 patients were identified; 42 underwent DS, 40 underwent SG, and 48 underwent GB. All groups had similar sex and comorbidity profiles, but the mean preoperative BMI was greatest in the DS group (mean = 52). At all intervals weight loss was greater in the DS group (P < .01), with a final BMI of 31 for the DS group, 31 for the SG group, and 28 for the GB group. Cholesterol and low-density lipoprotein showed significantly greater improvement at all time points with DS compared with SG and GB (P < .01). Baseline CRP levels among DS patients were double that of SG and GB, but rapidly declined to equivalent levels by 3 months and normalized in 79%. CONCLUSIONS: The DS procedure resulted in a superior reduction in cardiovascular and proinflammatory risk markers compared with GB and SG. Published by Elsevier Inc.
BACKGROUND:Obesity is associated with cardiovascular risk factors such as lipid levels and increased levels of C-reactive peptide (CRP). We hypothesized that duodenal switch (DS) would show equivalent or superior risk reduction compared with standard bariatric surgeries. METHODS:Patients underwent DS, sleeve gastrectomy (SG), or gastric bypass (GB) over a 2-year period. Body mass index (BMI), lipid panel, and CRP were measured preoperatively and then 3, 6, and 12 months postoperatively. RESULTS: A total of 130 patients were identified; 42 underwent DS, 40 underwent SG, and 48 underwent GB. All groups had similar sex and comorbidity profiles, but the mean preoperative BMI was greatest in the DS group (mean = 52). At all intervals weight loss was greater in the DS group (P < .01), with a final BMI of 31 for the DS group, 31 for the SG group, and 28 for the GB group. Cholesterol and low-density lipoprotein showed significantly greater improvement at all time points with DS compared with SG and GB (P < .01). Baseline CRP levels among DSpatients were double that of SG and GB, but rapidly declined to equivalent levels by 3 months and normalized in 79%. CONCLUSIONS: The DS procedure resulted in a superior reduction in cardiovascular and proinflammatory risk markers compared with GB and SG. Published by Elsevier Inc.
Authors: Henriette Frikke-Schmidt; Brian F Zamarron; Robert W O'Rourke; Darleen A Sandoval; Carey N Lumeng; Randy J Seeley Journal: Mol Metab Date: 2017-02-16 Impact factor: 7.422