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Literature DB >> 22405270

WTX: an unexpected regulator for p53.

Abstract

The WTX gene is frequently lost or mutated in Wilms tumor. In this issue of Molecular Cell, Kim et al. (2012) identify WTX modulation of p53 tumor-suppressor activity through regulation of p53 acetylation. Therefore, WTX differentially regulates the oncogenic β-catenin pathway and the tumor-suppressing p53 pathway. Copyright Â

Entities: CellLine Chemical Disease Gene Species

Year: 2012 PMID： 22405270 PMCID： PMC3632215 DOI： 10.1016/j.molcel.2012.02.010

Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970

10 in total

1. An X chromosome gene, WTX, is commonly inactivated in Wilms tumor.

Authors: Miguel N Rivera; Woo Jae Kim; Julie Wells; David R Driscoll; Brian W Brannigan; Moonjoo Han; James C Kim; Andrew P Feinberg; William L Gerald; Sara O Vargas; Lynda Chin; A John Iafrate; Daphne W Bell; Daniel A Haber
Journal: Science Date: 2007-01-04 Impact factor: 47.728

2. Acetylation is indispensable for p53 activation.

Authors: Yi Tang; Wenhui Zhao; Yue Chen; Yingming Zhao; Wei Gu
Journal: Cell Date: 2008-05-16 Impact factor: 41.582

3. The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification.

Authors: Annie Moisan; Miguel N Rivera; Sutada Lotinun; Sara Akhavanfard; Erik J Coffman; Edward B Cook; Svetlana Stoykova; Siddhartha Mukherjee; Jesse A Schoonmaker; Alexa Burger; Woo Jae Kim; Henry M Kronenberg; Roland Baron; Daniel A Haber; Nabeel Bardeesy
Journal: Dev Cell Date: 2011-05-17 Impact factor: 12.270

4. Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation.

Authors: Kristina Tanneberger; Astrid S Pfister; Katharina Brauburger; Jean Schneikert; Michel V Hadjihannas; Vitezslav Kriz; Gunnar Schulte; Vitezslav Bryja; Jürgen Behrens
Journal: EMBO J Date: 2011-02-08 Impact factor: 11.598

Review 5. Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene.

Authors: Vicki Huff
Journal: Nat Rev Cancer Date: 2011-01-20 Impact factor: 60.716

6. Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis.

Authors: Zandra A Jenkins; Margriet van Kogelenberg; Tim Morgan; Aaron Jeffs; Ryuji Fukuzawa; Esther Pearl; Christina Thaller; Anne V Hing; Mary E Porteous; Sixto Garcia-Miñaur; Axel Bohring; Didier Lacombe; Fiona Stewart; Torunn Fiskerstrand; Laurence Bindoff; Siren Berland; Lesley C Adès; Michel Tchan; Albert David; Louise C Wilson; Raoul C M Hennekam; Dian Donnai; Sahar Mansour; Valérie Cormier-Daire; Stephen P Robertson
Journal: Nat Genet Date: 2008-12-14 Impact factor: 38.330

Review 7. Modes of p53 regulation.

Authors: Jan-Philipp Kruse; Wei Gu
Journal: Cell Date: 2009-05-15 Impact factor: 41.582

8. Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.

Authors: Michael B Major; Nathan D Camp; Jason D Berndt; Xianhua Yi; Seth J Goldenberg; Charlotte Hubbert; Travis L Biechele; Anne-Claude Gingras; Ning Zheng; Michael J Maccoss; Stephane Angers; Randall T Moon
Journal: Science Date: 2007-05-18 Impact factor: 47.728

9. The WTX tumor suppressor enhances p53 acetylation by CBP/p300.

Authors: Woo Jae Kim; Miguel N Rivera; Erik J Coffman; Daniel A Haber
Journal: Mol Cell Date: 2012-01-26 Impact factor: 17.970

10. Inactivating mutations of acetyltransferase genes in B-cell lymphoma.

Authors: Laura Pasqualucci; David Dominguez-Sola; Annalisa Chiarenza; Giulia Fabbri; Adina Grunn; Vladimir Trifonov; Lawryn H Kasper; Stephanie Lerach; Hongyan Tang; Jing Ma; Davide Rossi; Amy Chadburn; Vundavalli V Murty; Charles G Mullighan; Gianluca Gaidano; Raul Rabadan; Paul K Brindle; Riccardo Dalla-Favera
Journal: Nature Date: 2011-03-10 Impact factor: 49.962

10 in total

1 in total

Review 1. RUNX Family Participates in the Regulation of p53-Dependent DNA Damage Response.

Authors: Toshinori Ozaki; Akira Nakagawara; Hiroki Nagase
Journal: Int J Genomics Date: 2013-09-03 Impact factor: 2.326

1 in total