| Literature DB >> 22405067 |
Julie St-Pierre1, Michel L Tremblay.
Abstract
Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity. Recent discoveries reveal that protein tyrosine phosphatases are key players in leptin resistance by globally suppressing leptin signaling. Copyright ÂEntities:
Mesh：
Substances：
Year: 2012 PMID： 22405067 DOI： 10.1016/j.cmet.2012.02.004
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287