Literature DB >> 22404522

Pharmacokinetic study of arctigenin in rat plasma and organ tissue by RP-HPLC method.

Fan He1, De-Qiang Dou, Qiang Hou, Yu Sun, Ting-Guo Kang.   

Abstract

A high-performance liquid chromatography (HPLC) technique was developed for the determination of arctigenin in plasma and various organs of rats after the oral administration of 30, 50 and 70 mgkg(-1) of arctigenin to the Sprague-Dawley rats. Results showed that the validated HPLC method was simple, fast, reproducible and suitable to the determination of arctigenin in rat plasma and organ tissue and one-compartmental model with zero-order absorption process can well describe the changes of arctigenin concentration in the plasma. The concentration of compound was highest in the spleen, less in the liver and the least in the lung.

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Year:  2012        PMID： 22404522     DOI： 10.1080/14786419.2012.666745

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  7 in total

1.  Elucidation of arctigenin pharmacokinetics after intravenous and oral administrations in rats: integration of in vitro and in vivo findings via semi-mechanistic pharmacokinetic modeling.

Authors:  Qiong Gao; Yufeng Zhang; Siukwan Wo; Zhong Zuo
Journal:  AAPS J       Date:  2014-10-02       Impact factor: 4.009

Review 2.  Overview of the anti-inflammatory effects, pharmacokinetic properties and clinical efficacies of arctigenin and arctiin from Arctium lappa L.

Authors:  Qiong Gao; Mengbi Yang; Zhong Zuo
Journal:  Acta Pharmacol Sin       Date:  2018-04-26       Impact factor: 6.150

3.  Arctigenin prevents monocrotaline-induced pulmonary arterial hypertension in rats.

Authors:  Wei-Long Jiang; Xiao Han; Yu-Feng Zhang; Qing-Qing Xia; Jia-Ming Zhang; Feng Wang
Journal:  RSC Adv       Date:  2019-01-02       Impact factor: 3.361

4.  Elucidation of Arctigenin Pharmacokinetics and Tissue Distribution after Intravenous, Oral, Hypodermic and Sublingual Administration in Rats and Beagle Dogs: Integration of In Vitro and In Vivo Findings.

Authors:  Jie Li; Xin Li; Yu-Shan Ren; Yuan-Yuan Lv; Jun-Sheng Zhang; Xiao-Li Xu; Xian-Zhen Wang; Jing-Chun Yao; Gui-Min Zhang; Zhong Liu
Journal:  Front Pharmacol       Date:  2017-06-14       Impact factor: 5.810

5.  28-Day Oral Chronic Toxicity Study of Arctigenin in Rats.

Authors:  Yu-Jun Tan; Yu-Shan Ren; Lei Gao; Lan-Fang Li; Li-Juan Cui; Bin Li; Xin Li; Jian Yang; Ming-Zhi Wang; Yuan-Yuan Lv; Xiao-Li Xu; Jing-Chun Yao; Zhong Liu; Gui-Min Zhang; Jie Li
Journal:  Front Pharmacol       Date:  2018-09-26       Impact factor: 5.810

6.  Pharmacokinetics of Arctigenin and Fructus Arctii Powder in Piglets.

Authors:  Bin He; Hai-Jing Zhang; Wen-Hai Yang; Zhi-Yong Shao; Li-Jun Wu; Xia-Bing Chen; Jie Chen; Wu Liu; Zhi-Ping Ran; Rr-Guang Jin; Ji-Yue Cao
Journal:  Front Vet Sci       Date:  2019-07-25

7.  Arctigenin prevents the progression of osteoarthritis by targeting PI3K/Akt/NF-κB axis: In vitro and in vivo studies.

Authors:  Shangkun Tang; Weijun Zhou; Xinyang Zhong; Jianchen Xu; Huasong Huang; Xinnan Zheng; Jingkang Zhang; Shuyue Yang; Ping Shang; Qian Tang; Haixiao Liu
Journal:  J Cell Mol Med       Date:  2020-02-24       Impact factor: 5.310
  7 in total

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