BACKGROUND: There are conflicting data that suggest that hyperoxia may be associated with either worse or better outcomes in patients suffering a stroke. OBJECTIVES: To investigate the association between PaO(2) in the first 24 hours in the intensive care unit and mortality among ventilated patients with acute ischaemic stroke. DESIGN: Retrospective cohort study. SETTING: Data were extracted from the Australian and New Zealand Intensive Care Society Adult Patient Database. PARTICIPANTS: Adults ventilated for ischaemic stroke in 129 ICUs in Australia and New Zealand, 2000-2009. MAIN OUTCOME MEASURES: The primary outcome was the odds ratio for in hospital mortality associated with "worst" PaO(2) considered as a categorical variable, with data divided into deciles and compared with the mortality of the 10th decile. For patients on an FiO(2) of _50% at any time in the first 24 hours, "worst" PaO(2) was defined as the PaO(2) associated with the highest alveolar-arterial (A-a) gradient. For patients on an FiO(2) of <50%, it was defined as the lowest PaO(2). Secondary outcomes were ICU and hospital length of stay and the proportion of patients in each decile discharged home. RESULTS: Of the 2643 patients eligible for study inclusion, 1507 (57%) died in hospital. The median "worst" PaO(2) was 117mmHg (interquartile range, 87-196mmHg). There was no association between worst PaO(2) and mortality, length of stay or likelihood of discharge home. CONCLUSIONS: We found no association between worst arterial oxygen tension in the first 24 hours in ICU and outcome in ventilated patients with ischaemic stroke.
BACKGROUND: There are conflicting data that suggest that hyperoxia may be associated with either worse or better outcomes in patients suffering a stroke. OBJECTIVES: To investigate the association between PaO(2) in the first 24 hours in the intensive care unit and mortality among ventilated patients with acute ischaemic stroke. DESIGN: Retrospective cohort study. SETTING: Data were extracted from the Australian and New Zealand Intensive Care Society Adult Patient Database. PARTICIPANTS: Adults ventilated for ischaemic stroke in 129 ICUs in Australia and New Zealand, 2000-2009. MAIN OUTCOME MEASURES: The primary outcome was the odds ratio for in hospital mortality associated with "worst" PaO(2) considered as a categorical variable, with data divided into deciles and compared with the mortality of the 10th decile. For patients on an FiO(2) of _50% at any time in the first 24 hours, "worst" PaO(2) was defined as the PaO(2) associated with the highest alveolar-arterial (A-a) gradient. For patients on an FiO(2) of <50%, it was defined as the lowest PaO(2). Secondary outcomes were ICU and hospital length of stay and the proportion of patients in each decile discharged home. RESULTS: Of the 2643 patients eligible for study inclusion, 1507 (57%) died in hospital. The median "worst" PaO(2) was 117mmHg (interquartile range, 87-196mmHg). There was no association between worst PaO(2) and mortality, length of stay or likelihood of discharge home. CONCLUSIONS: We found no association between worst arterial oxygen tension in the first 24 hours in ICU and outcome in ventilated patients with ischaemic stroke.
Authors: Layne Dylla; Jeremy T Cushman; Beau Abar; Curtis Benesch; Courtney M C Jones; M Kerry O'Banion; David H Adler Journal: Am J Emerg Med Date: 2020-07-11 Impact factor: 2.469
Authors: Layne Dylla; David H Adler; Beau Abar; Curtis Benesch; Courtney M C Jones; M Kerry O'Banion; Jeremy T Cushman Journal: Am J Emerg Med Date: 2019-11-18 Impact factor: 2.469
Authors: R Sonneville; M Mazighi; D Bresson; I Crassard; S Crozier; E de Montmollin; V Degos; F Faugeras; E Gayat; L Josse; C Lamy; E Magalhaes; A Maldjian; S Ruckly; J Servan; P Vassel; B Vigué; J-F Timsit; F Woimant Journal: Neurocrit Care Date: 2020-04 Impact factor: 3.210
Authors: Marija Barbateskovic; Olav L Schjørring; Sara Russo Krauss; Janus C Jakobsen; Christian S Meyhoff; Rikke M Dahl; Bodil S Rasmussen; Anders Perner; Jørn Wetterslev Journal: Cochrane Database Syst Rev Date: 2019-11-27
Authors: Hendrik J F Helmerhorst; Marcus J Schultz; Peter H J van der Voort; Evert de Jonge; David J van Westerloo Journal: Crit Care Date: 2015-08-17 Impact factor: 9.097
Authors: Hendrik Jf Helmerhorst; Marcus J Schultz; Peter Hj van der Voort; Robert J Bosman; Nicole P Juffermans; Evert de Jonge; David J van Westerloo Journal: Ann Intensive Care Date: 2014-07-25 Impact factor: 6.925