Literature DB >> 22403424

Analysis of transmitted resistance to raltegravir and selective pressure among HIV-1-infected patients on a failing HAART in Sao Paulo, Brazil.

N P Mantovani1, R G Azevedo, J T Rabelato, S Sanabani, R S Diaz, S V Komninakis.   

Abstract

We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance.

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Year:  2012        PMID： 22403424      PMCID： PMC3372140          DOI： 10.1128/JCM.00539-12

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  11 in total

1.  Specific HIV-1 integrase polymorphisms change their prevalence in untreated versus antiretroviral-treated HIV-1-infected patients, all naive to integrase inhibitors.

Authors:  Francesca Ceccherini-Silberstein; Isabelle Malet; Lavinia Fabeni; Salvatore Dimonte; Valentina Svicher; Roberta D'Arrigo; Anna Artese; Giosuè Costa; Sara Bono; Stefano Alcaro; Antonella d'Arminio Monforte; Christine Katlama; Vincent Calvez; Andrea Antinori; Anne-Genevieve Marcelin; Carlo-Federico Perno
Journal:  J Antimicrob Chemother       Date:  2010-09-03       Impact factor: 5.790

Review 2.  HIV-1 drug resistance mutations: an updated framework for the second decade of HAART.

Authors:  Robert W Shafer; Jonathan M Schapiro
Journal:  AIDS Rev       Date:  2008 Apr-Jun       Impact factor: 2.500

3.  Lack of primary mutations associated with integrase inhibitors among HIV-1 subtypes B, C, and F circulating in Brazil.

Authors:  Caroline Bittencourt Passaes; Monick Lindenmeyer Guimarães; Saada Lima Chequer Fernandez; Roberta Dos Santos Lorete; Sylvia Lopes Maia Teixeira; José Carlos Couto Fernandez; Mariza Gonçalves Morgado
Journal:  J Acquir Immune Defic Syndr       Date:  2009-05-01       Impact factor: 3.731

4.  Genotypic/phenotypic patterns of HIV-1 integrase resistance to raltegravir.

Authors:  Filippo Canducci; Maria Chiara Marinozzi; Michela Sampaolo; Enzo Boeri; Vincenzo Spagnuolo; Nicola Gianotti; Antonella Castagna; Stefania Paolucci; Fausto Baldanti; Adriano Lazzarin; Massimo Clementi
Journal:  J Antimicrob Chemother       Date:  2010-01-07       Impact factor: 5.790

5.  HIV-1 genetic diversity and drug resistance among treatment naïve patients from Southern Brazil: an association of HIV-1 subtypes with exposure categories.

Authors:  Tiago Gräf; Caroline P B Passaes; Luis G E Ferreira; Edmundo C Grisard; Mariza G Morgado; Gonzalo Bello; Aguinaldo R Pinto
Journal:  J Clin Virol       Date:  2011-05-31       Impact factor: 3.168

6.  The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.

Authors:  J D Thompson; T J Gibson; F Plewniak; F Jeanmougin; D G Higgins
Journal:  Nucleic Acids Res       Date:  1997-12-15       Impact factor: 16.971

7.  Integrase variability and susceptibility to HIV integrase inhibitors: impact of subtypes, antiretroviral experience and duration of HIV infection.

Authors:  Carolina Garrido; Anna Maria Geretti; Natalia Zahonero; Clare Booth; Angela Strang; Vincent Soriano; Carmen De Mendoza
Journal:  J Antimicrob Chemother       Date:  2009-12-09       Impact factor: 5.790

8.  Evolution of raltegravir resistance during therapy.

Authors:  Nadine Sichtig; Saleta Sierra; Rolf Kaiser; Martin Däumer; Stefan Reuter; Eugen Schülter; Andre Altmann; Gerd Fätkenheuer; Ulf Dittmer; Herbert Pfister; Stefan Esser
Journal:  J Antimicrob Chemother       Date:  2009-05-14       Impact factor: 5.790

9.  Genetic diversity on the integrase region of the pol gene among HIV type 1-infected patients naive for integrase inhibitors in São Paulo City, Brazil.

Authors:  Liã Bárbara Arruda; Luiz Augusto M Fonseca; Alberto J S Duarte; Jorge Casseb
Journal:  AIDS Res Hum Retroviruses       Date:  2010-01       Impact factor: 2.205

10.  Natural polymorphisms of human immunodeficiency virus type 1 integrase and inherent susceptibilities to a panel of integrase inhibitors.

Authors:  Andrea Low; Nicole Prada; Michael Topper; Florin Vaida; Delivette Castor; Hiroshi Mohri; Daria Hazuda; Mark Muesing; Martin Markowitz
Journal:  Antimicrob Agents Chemother       Date:  2009-08-03       Impact factor: 5.191
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  2 in total

1.  Novel Approaches for Visualizing and Analyzing Dose-Timing Data from Electronic Drug Monitors, or "How the 'Broken Window' Theory Pertains to ART Adherence".

Authors:  Christopher J Gill; Mary Bachman DeSilva; Davidson H Hamer; Xu Keyi; Ira B Wilson; Lora Sabin
Journal:  AIDS Behav       Date:  2015-11

2.  HIV-1 integrase resistance among antiretroviral treatment naive and experienced patients from Northwestern Poland.

Authors:  Miłosz Parczewski; Dorota Bander; Anna Urbańska; Anna Boroń-Kaczmarska
Journal:  BMC Infect Dis       Date:  2012-12-21       Impact factor: 3.090
  2 in total

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