BACKGROUND: Few studies have addressed the relationship between generalised anxiety disorder and cardiovascular prognosis using a diagnostic interview. AIMS: To assess the association between generalised anxiety disorder and adverse outcomes in patients with myocardial infarction. METHOD: Patients with acute myocardial infarction (n = 438) were recruited between 1997 and 2000 and were followed up until 2007. Current generalised anxiety disorder and post-myocardial infarction depression were assessed with the Composite International Diagnostic Interview. The end-point consisted of all-cause mortality and cardiovascular-related readmissions. RESULTS: During the follow-up period, 198 patients had an adverse event. Generalised anxiety disorder was associated with an increased rate of adverse events after adjustment for age and gender (hazard ratio: 1.94; 95% confidence interval: 1.14-3.30; P = 0.01). Additional adjustment for measures of cardiac disease severity and depression did not change the results. CONCLUSIONS: Generalised anxiety disorder was associated with an almost twofold increased risk of adverse outcomes independent demographic and clinical variables and depression.
BACKGROUND: Few studies have addressed the relationship between generalised anxiety disorder and cardiovascular prognosis using a diagnostic interview. AIMS: To assess the association between generalised anxiety disorder and adverse outcomes in patients with myocardial infarction. METHOD:Patients with acute myocardial infarction (n = 438) were recruited between 1997 and 2000 and were followed up until 2007. Current generalised anxiety disorder and post-myocardial infarction depression were assessed with the Composite International Diagnostic Interview. The end-point consisted of all-cause mortality and cardiovascular-related readmissions. RESULTS: During the follow-up period, 198 patients had an adverse event. Generalised anxiety disorder was associated with an increased rate of adverse events after adjustment for age and gender (hazard ratio: 1.94; 95% confidence interval: 1.14-3.30; P = 0.01). Additional adjustment for measures of cardiac disease severity and depression did not change the results. CONCLUSIONS: Generalised anxiety disorder was associated with an almost twofold increased risk of adverse outcomes independent demographic and clinical variables and depression.
Authors: Christina M DuBois; Oriana Vesga Lopez; Eleanor E Beale; Brian C Healy; Julia K Boehm; Jeff C Huffman Journal: Int J Cardiol Date: 2015-05-21 Impact factor: 4.164
Authors: Christopher M Celano; Ana C Villegas; Ariana M Albanese; Hanna K Gaggin; Jeff C Huffman Journal: Harv Rev Psychiatry Date: 2018 Jul/Aug Impact factor: 3.732
Authors: Rachel A Millstein; Christopher M Celano; Eleanor E Beale; Scott R Beach; Laura Suarez; Arianna M Belcher; James L Januzzi; Jeff C Huffman Journal: Gen Hosp Psychiatry Date: 2016-08-30 Impact factor: 3.238
Authors: Christopher M Celano; Daniel J Daunis; Hermioni N Lokko; Kirsti A Campbell; Jeff C Huffman Journal: Curr Psychiatry Rep Date: 2016-11 Impact factor: 5.285