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Literature DB >> 22402943

Drosophila: a model for understanding obesity and diabetic complications.

Abstract

The molecular mechanisms underlying development of obesity and diabetic complications are not well understood. Drosophila has become a popular model organism for studying a variety of human diseases. We discuss here emerging Drosophila models of obesity and diabetic complications. © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York.

Entities: Disease Species

Mesh：

Substances：
Dietary Carbohydrates

Year: 2012 PMID： 22402943 DOI： 10.1055/s-0032-1304566

Source DB: PubMed Journal: Exp Clin Endocrinol Diabetes ISSN： 0947-7349 Impact factor: 2.949

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Cited

14 in total

1. Ancestral and offspring nutrition interact to affect life-history traits in Drosophila melanogaster.

Authors: Joseph B Deas; Leo Blondel; Cassandra G Extavour
Journal: Proc Biol Sci Date: 2019-02-27 Impact factor: 5.349

2. Invertebrate models for coenzyme q10 deficiency.

Authors: Daniel J M Fernández-Ayala; Sandra Jiménez-Gancedo; Ignacio Guerra; Plácido Navas
Journal: Mol Syndromol Date: 2014-07

Review 3. From fat fruit fly to human obesity.

Authors: Wanli W Smith; Joseph Thomas; Jingnan Liu; Tianxia Li; Timothy H Moran
Journal: Physiol Behav Date: 2014-02-06

4. Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood.

Authors: Gilles Storelli; Hyuck-Jin Nam; Judith Simcox; Claudio J Villanueva; Carl S Thummel
Journal: Dev Cell Date: 2018-12-13 Impact factor: 12.270

5. The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults.

Authors: William E Barry; Carl S Thummel
Journal: Elife Date: 2016-05-17 Impact factor: 8.140

Drosophila: a model for understanding obesity and diabetic complications.

1. Ancestral and offspring nutrition interact to affect life-history traits in Drosophila melanogaster.

2. Invertebrate models for coenzyme q10 deficiency.

Review 3. From fat fruit fly to human obesity.

4. Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood.

5. The Drosophila HNF4 nuclear receptor promotes glucose-stimulated insulin secretion and mitochondrial function in adults.

6. Insulin and Leptin/Upd2 Exert Opposing Influences on Synapse Number in Fat-Sensing Neurons.

7. Diet modification and metformin have a beneficial effect in a fly model of obesity and mucormycosis.

Review 8. Drosophila melanogaster as a Model for Diabetes Type 2 Progression.

Review 9. Answering the ultimate question "what is the proximal cause of aging?".

10. Rapamycin extends life- and health span because it slows aging.