BACKGROUND: Congenital abnormalities of the kidney and urinary tract (CAKUT) are significant causes of morbidity. The aim of the study was to determine predictive factors of mortality in newborns with CAKUT. METHODS: All 29,653 consecutive newborns hospitalized in a tertiary neonatal unit between 1996 and 2006 were evaluated. The main outcome was neonatal mortality. The variables analyzed as risk factors were maternal age, first pregnancy, low birth weight (LBW), prematurity, oligohydramnios, and CAKUT associated with other malformations (Associated CAKUT). RESULTS: CAKUT was detected in 524 newborns, with an overall prevalence of 17.7 per 1,000 live births. A total of 325 (62%) cases were classified as urinary tract dilatation, 79 (15.1%) as renal cystic disease, and 120 (22.9%) as other subgroups. In the urinary tract dilatation subgroup, independent risk factors for early mortality were Associated CAKUT [odds ratio (OR) 20.7], prematurity (OR 4.5) LBW (OR 3.8), oligohydramnios (OR 3.0), and renal involvement (OR 3.0). In the renal cystic disease subgroup, two variables remained associated with neonatal mortality: LBW (OR 12.3) and Associated CAKUT (OR 21.4). CONCLUSION: The presence of extrarenal anomalies was a strong predictor of poor outcome in a larger series of infants with CAKUT.
BACKGROUND:Congenital abnormalities of the kidney and urinary tract (CAKUT) are significant causes of morbidity. The aim of the study was to determine predictive factors of mortality in newborns with CAKUT. METHODS: All 29,653 consecutive newborns hospitalized in a tertiary neonatal unit between 1996 and 2006 were evaluated. The main outcome was neonatal mortality. The variables analyzed as risk factors were maternal age, first pregnancy, low birth weight (LBW), prematurity, oligohydramnios, and CAKUT associated with other malformations (Associated CAKUT). RESULTS: CAKUT was detected in 524 newborns, with an overall prevalence of 17.7 per 1,000 live births. A total of 325 (62%) cases were classified as urinary tract dilatation, 79 (15.1%) as renal cystic disease, and 120 (22.9%) as other subgroups. In the urinary tract dilatation subgroup, independent risk factors for early mortality were Associated CAKUT [odds ratio (OR) 20.7], prematurity (OR 4.5) LBW (OR 3.8), oligohydramnios (OR 3.0), and renal involvement (OR 3.0). In the renal cystic disease subgroup, two variables remained associated with neonatal mortality: LBW (OR 12.3) and Associated CAKUT (OR 21.4). CONCLUSION: The presence of extrarenal anomalies was a strong predictor of poor outcome in a larger series of infants with CAKUT.
Authors: E A Oliveira; J S Diniz; A C Cabral; A K Pereira; H V Leite; E A Colosimo; A S Vilasboas Journal: Fetal Diagn Ther Date: 2000 May-Jun Impact factor: 2.587
Authors: E A Oliveira; J S Diniz; A C Cabral; H V Leite; E A Colosimo; R B Oliveira; A S Vilasboas Journal: Pediatr Nephrol Date: 1999-11 Impact factor: 3.714
Authors: Eli Armando S Rabelo; Eduardo A Oliveira; José Silvério S Diniz; José Maria P Silva; Maria Tereza Freire Filgueiras; Isabela Leite Pezzuti; Edson Samesina Tatsuo Journal: Pediatr Nephrol Date: 2004-07-16 Impact factor: 3.714
Authors: Débora Marques de Miranda; Augusto César Soares Dos Santos Júnior; Geisilaine Soares Dos Reis; Izabella Silva Freitas; Thiago Guimarães Rosa Carvalho; Luiz Armando Cunha de Marco; Eduardo Araújo Oliveira; Ana Cristina Simões E Silva Journal: Mol Diagn Ther Date: 2014-08 Impact factor: 4.074
Authors: Isabel G Quirino; Cristiane S Dias; Mariana A Vasconcelos; Isabel V Poggiali; Kerlane C Gouvea; Alamanda K Pereira; Gabriela P Paulinelli; Amanda R Moura; Raquel S Ferreira; Enrico A Colosimo; Ana Cristina Simões E Silva; Eduardo A Oliveira Journal: Pediatr Nephrol Date: 2014-06-19 Impact factor: 3.714