| Literature DB >> 22401806 |
Ho-Jin Moon1, Jong-Soo Lee, Young-Ki Choi, Jie-Yeun Park, Melbourne R Talactac, Mohammed Y E Chowdhury, Haryoung Poo, Moon-Hee Sung, Ji-Hoon Lee, Jae U Jung, Chul-Joong Kim.
Abstract
In addition to development of vaccines and synthetic antiviral drugs, recent studies have advocated the use of natural substances that inhibit or prevent viral infections. High-molecular-weight poly-γ-glutamate (HM-γ-PGA) produced by Bacillus subtilis chungkookjang was evaluated for anti-influenza virus activity. HM-γ-PGA induced type I interferons (IFNs), which in turn stimulated expression of Myxovirus resistant 1 protein and IFN-related proteins in vitro. In the B6.A2G-Mx1 mouse model, which mimics the innate immune system of humans, treatment with HM-γ-PGA enhanced the antiviral state of mice and protected them against highly pathogenic influenza A virus. Naturally synthesized HM-γ-PGA has potent anti-influenza activity and may be a useful means for control of influenza virus.Entities:
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Year: 2012 PMID： 22401806 DOI： 10.1016/j.antiviral.2012.02.010
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970