BACKGROUND: Dome-type carcinoma (DC) is a distinct variant of colorectal adenocarcinoma and less than 10 cases have been described in the literature. Most of the previously reported cases were early lesions and no endoscopic observations have been described so far. We herein report a case of a DC invading the subserosal layer, including endoscopic findings. CASE PRESENTATION: A highly elevated lesion in the transverse colon was diagnosed by colonoscopy in a 77-year-old man. The tumor appeared to be similar to a submucosal tumor (SMT), however, a demarcated area of reddish and irregular mucosa was observed at the top of the tumor. There were no erosions or ulcers. Laparoscopic-assisted right hemicolectomy was performed and pathological examination revealed a well-circumscribed tumor invading the subserosal layer. The tumor was a well-differentiated adenocarcinoma associated with a dense lymphocytic infiltration and showed expansive growth. The overlying mucosal layer showed high-grade dysplasia. CONCLUSION: The present lesion was diagnosed as a DC of the colon invading the subserosal layer. Because the association of mucosal dysplasia is common in DCs, the detection of dysplastic epithelium would be important to discriminate DCs from SMTs.
BACKGROUND:Dome-type carcinoma (DC) is a distinct variant of colorectal adenocarcinoma and less than 10 cases have been described in the literature. Most of the previously reported cases were early lesions and no endoscopic observations have been described so far. We herein report a case of a DC invading the subserosal layer, including endoscopic findings. CASE PRESENTATION: A highly elevated lesion in the transverse colon was diagnosed by colonoscopy in a 77-year-old man. The tumor appeared to be similar to a submucosal tumor (SMT), however, a demarcated area of reddish and irregular mucosa was observed at the top of the tumor. There were no erosions or ulcers. Laparoscopic-assisted right hemicolectomy was performed and pathological examination revealed a well-circumscribed tumor invading the subserosal layer. The tumor was a well-differentiated adenocarcinoma associated with a dense lymphocytic infiltration and showed expansive growth. The overlying mucosal layer showed high-grade dysplasia. CONCLUSION: The present lesion was diagnosed as a DC of the colon invading the subserosal layer. Because the association of mucosal dysplasia is common in DCs, the detection of dysplastic epithelium would be important to discriminate DCs from SMTs.
Authors: Hala Kannuna; Carlos A Rubio; Patricia Caseiro Silverio; Marc Girardin; Nicolas Goossens; Laura Rubbia-Brandt; Giacomo Puppa Journal: Diagn Pathol Date: 2015-07-09 Impact factor: 2.644
Authors: Aline Simoneti Fonseca; Anelisa Ramão; Matheus Carvalho Bürger; Jorge Estefano Santana de Souza; Dalila Lucíola Zanette; Greice Andreotti de Molfetta; Luiza Ferreira de Araújo; Rafaela de Barros E Lima Bueno; Graziela Moura Aguiar; Jessica Rodrigues Plaça; Cleidson de Pádua Alves; Anemari Ramos Dinarte Dos Santos; Daniel Onofre Vidal; Gyl Eanes Barros Silva; Rodrigo Alexandre Panepucci; Fernanda Maris Peria; Omar Feres; José Joaquim Ribeiro da Rocha; Marco Antonio Zago; Wilson Araújo Silva Journal: BMC Cancer Date: 2021-03-01 Impact factor: 4.430