Literature DB >> 22398575

Collagen VI encodes antimicrobial activity: novel innate host defense properties of the extracellular matrix.

Suado M Abdillahi1, Selma Balvanović, Maria Baumgarten, Matthias Mörgelin.   

Abstract

Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate Immun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense.
Copyright © 2012 S. Karger AG, Basel.

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Year:  2012        PMID: 22398575      PMCID: PMC6741453          DOI: 10.1159/000335239

Source DB:  PubMed          Journal:  J Innate Immun        ISSN: 1662-811X            Impact factor:   7.349


  25 in total

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8.  Collagen VI is a subepithelial adhesive target for human respiratory tract pathogens.

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Journal:  J Innate Immun       Date:  2009-08-01       Impact factor: 7.349

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4.  The Pulmonary Extracellular Matrix Is a Bactericidal Barrier Against Haemophilus influenzae in Chronic Obstructive Pulmonary Disease (COPD): Implications for an in vivo Innate Host Defense Function of Collagen VI.

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