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Literature DB >> 223977

Studies on the mechanism of macrophage aggregation induced by lymphokines.

Abstract

Macrophage aggregation (measured by a light-scattering technique) induced by unpurified lymphokine preparations has been investigated. This has been shown to be Ca2+ or Mg2+ dependent and to be inhibited by a number of agents known to affect cellular physiology and biochemistry. The divalent cation ionophore A23187 causes a macrophage aggregation superficially similar to that induced by lymphokines, although differences were found. It is suggested that a biochemical response by the macrophage is required for aggregation induced by lymphokines, and thus measurements of macrophage aggregation allow a study of the early events in the response of macrophages to lymphokines.

Entities: Chemical Gene

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Year: 1979 PMID： 223977 PMCID： PMC1457488

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

16 in total

1. Evidence for cyclic GMP and calcium mediation of lymphocyte activation by mitogens.

Authors: R G Coffey; E M Hadden; J W Hadden
Journal: J Immunol Date: 1977-10 Impact factor: 5.422

2. Influence of inhibitors of cellular function on chemotactic factor-induced neutrophil aggregation.

Authors: J T O'Flaherty; D L Kreutzer; H J Showell; P A Ward
Journal: J Immunol Date: 1977-11 Impact factor: 5.422

3. A sensitive technique for measuring specific macrophage aggregation: a comparison with macrophage migration inhibition, for the detection of lymphokine activity.

Authors: B Rouveix; P Badenoch-Jones; J L Turk
Journal: Immunology Date: 1979-03 Impact factor: 7.397

4. Role of lymphocyte activation products (LAP) in cell-mediated immunity. I. Preparation and partial purification of guinea-pig LAP.

Authors: D C Dumonde; D A Page; M Matthew; R A Wolstencroft
Journal: Clin Exp Immunol Date: 1972-01 Impact factor: 4.330

8. The mechanism of action of soluble lymphocyte mediators. IV. Effect of migratio inhibitory factor (MIF) on macrophage cyclic AMP and on responsiveness to adenylate cyclase stimulators.

Authors: E Pick
Journal: Cell Immunol Date: 1977-08 Impact factor: 4.868

9. The mechanism of action of soluble lymphocyte mediators. V. Mechanism of refractoriness to adenylate cyclase stimulators induced by migration inhibitory factor (MIF).

Authors: E Pick; A Grunspan-Swirsky
Journal: Cell Immunol Date: 1977-08 Impact factor: 4.868

10. 2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory effects of 2-deoxyglucose on phagocytosis and ATP generation.

Authors: J Michl; D J Ohlbaum; S C Silverstein
Journal: J Exp Med Date: 1976-12-01 Impact factor: 14.307

3 in total

Studies on the mechanism of macrophage aggregation induced by lymphokines.

1. Evidence for cyclic GMP and calcium mediation of lymphocyte activation by mitogens.

2. Influence of inhibitors of cellular function on chemotactic factor-induced neutrophil aggregation.

3. A sensitive technique for measuring specific macrophage aggregation: a comparison with macrophage migration inhibition, for the detection of lymphokine activity.

4. Role of lymphocyte activation products (LAP) in cell-mediated immunity. I. Preparation and partial purification of guinea-pig LAP.

5. Colchicine-binding proteins in chromatin and membranes.

6. Cytoskeletal regulation of concanavalin A capping in pulmonary alveolar macrophages.

7. Requirement for magnesium influx in activation of alveolar macrophages mediated by ionophore A23187.

8. The mechanism of action of soluble lymphocyte mediators. IV. Effect of migratio inhibitory factor (MIF) on macrophage cyclic AMP and on responsiveness to adenylate cyclase stimulators.

9. The mechanism of action of soluble lymphocyte mediators. V. Mechanism of refractoriness to adenylate cyclase stimulators induced by migration inhibitory factor (MIF).

10. 2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory effects of 2-deoxyglucose on phagocytosis and ATP generation.

1. Macrophage aggregation factor: some properties.

2. Lymphokine-induced macrophage aggregation: involvement of cyclic-GMP and microtubules.

3. Lymphokine-induced neutrophil aggregation.