Literature DB >> 22396707

Chronic critical limb ischemia.

Arndt Dohmen1, Stephan Eder, Wulf Euringer, Thomas Zeller, Friedhelm Beyersdorf.   

Abstract

BACKGROUND: Some 40 000 lower limb amputations are performed in Germany each year, 70% of them in diabetics. About 80% of all major amputations may be preventable with the use of new interventional and vascular surgical procedures, particularly on the arteries of the leg and foot. We present the current state of the art in revascularization techniques and evaluate their usefulness for preservation of the lower limb.
METHODS: This overview is based on the guidelines for the diagnosis and treatment of peripheral artery disease (PAD) and diabetic foot syndrome (DFS) that have been issued by the American Heart Association (AHA), the American College of Cardiology (ACC), the German Society of Angiology (DGA), the Trans-Atlantic Intersociety Consensus (TASC II), the German Society of Vascular Surgery (DGG), and the German Diabetes Society (DDG). A selective search in PubMed for relevant articles that appeared from 2000 to 2011 was conducted with the search terms "pedal bypass," "vascular intervention crural pedal," and "crural-pedal revascularization."
RESULTS: Most of the data on crural and pedal revascularization are derived from small-scale studies. The few comparative studies of interventional treatments and bypass surgery have not revealed any significant differences in outcome, but all studies of revascularization have shown good success rates for lower limb preservation.
CONCLUSION: Though the data are still sparse, the high reported rates of limb preservation imply that peripheral revascularization techniques can play a major role in the treatment of chronic critical limb ischemia (CLI). Therefore, these techniques are recommended without exception by the current guidelines.

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Year:  2012        PMID: 22396707      PMCID: PMC3295209          DOI: 10.3238/arztebl.2012.0095

Source DB:  PubMed          Journal:  Dtsch Arztebl Int        ISSN: 1866-0452            Impact factor:   5.594


  32 in total

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2.  One year outcome after primary stenting of infrapopliteal lesions with the Chromis Deep stent in the management of critical limb ischaemia.

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9.  Sirolimus-eluting versus bare stents after suboptimal infrapopliteal angioplasty for critical limb ischemia: enduring 1-year angiographic and clinical benefit.

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3.  Neither procedure is superior.

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4.  Continuous control.

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Journal:  Dtsch Arztebl Int       Date:  2012-08-20       Impact factor: 5.594

5.  Highly effective.

Authors:  Donatus Cyron; Martin Storck
Journal:  Dtsch Arztebl Int       Date:  2012-08-20       Impact factor: 5.594

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Review 7.  A review of the pathophysiology and potential biomarkers for peripheral artery disease.

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8.  IGF-1C domain-modified hydrogel enhances therapeutic potential of mesenchymal stem cells for hindlimb ischemia.

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9.  MiR-323b-5p acts as a novel diagnostic biomarker for critical limb ischemia in type 2 diabetic patients.

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  9 in total

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