Ali Reza Khalatbary1, Hassan Ahmadvand2. 1. Dept. of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Khazar Boulevard, Sari, Iran. 2. Dept. of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Abstract
BACKGROUND: Neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (SCI) and these cells cause substantial secondary tissue damage. The purpose of this study was to determine the effect of oleuropein (OE) on myeloperoxidase (MPO) activity as an index of neutrophil infiltration. METHODS: Rats were randomly divided into four groups of 7 rats each as follows: sham-operated group, trauma group, and OE treatment groups (20 mg/kg, i.p., immediately and 1 hour after SCI). Spinal cord samples were taken 24 hours after injury and studied for determination of MPO activity. RESULTS: The results showed that MPO activity was significantly decreased in OE-treated rats. CONCLUSION: On the basis of our findings, we propose that OE may be effective in protecting rat spinal cord from secondary damage by modulating of neutrophil infiltration.
BACKGROUND: Neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (SCI) and these cells cause substantial secondary tissue damage. The purpose of this study was to determine the effect of oleuropein (OE) on myeloperoxidase (MPO) activity as an index of neutrophil infiltration. METHODS:Rats were randomly divided into four groups of 7 rats each as follows: sham-operated group, trauma group, and OE treatment groups (20 mg/kg, i.p., immediately and 1 hour after SCI). Spinal cord samples were taken 24 hours after injury and studied for determination of MPO activity. RESULTS: The results showed that MPO activity was significantly decreased in OE-treated rats. CONCLUSION: On the basis of our findings, we propose that OE may be effective in protecting rat spinal cord from secondary damage by modulating of neutrophil infiltration.
Authors: Jennifer C Fleming; Michael D Norenberg; David A Ramsay; Gregory A Dekaban; Alexander E Marcillo; Alvaro D Saenz; Melissa Pasquale-Styles; W Dalton Dietrich; Lynne C Weaver Journal: Brain Date: 2006-10-28 Impact factor: 13.501
Authors: J A González-Correa; J Muñoz-Marín; M M Arrebola; A Guerrero; F Narbona; J A López-Villodres; J P De La Cruz Journal: Lipids Date: 2007-08-07 Impact factor: 1.646