First per-6-O-tritylation of cyclodextrins.

Because of the large dimension of the trityl group and the truncated conical geometry of cyclodextrin (CD) molecules, it is unclear if there is enough space at the narrower end of CDs to permit a per-6-O-tritylation. This work demonstrates that it is indeed possible to simultaneously install a trityl group at the O6-position of every glucopyranosyl unit in a CD. A novel per-6-substitution method has been developed for CD chemistry.