Literature DB >> 22394077

Bruton's tyrosine kinase inhibitors: approaches to potent and selective inhibition, preclinical and clinical evaluation for inflammatory diseases and B cell malignancies.

Yan Lou1, Timothy D Owens, Andreas Kuglstatter, Rama K Kondru, David M Goldstein.   

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Year:  2012        PMID： 22394077     DOI： 10.1021/jm300035p

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  13 in total

1.  Noncovalent inhibitors reveal BTK gatekeeper and auto-inhibitory residues that control its transforming activity.

Authors:  Shenqiu Wang; Sayan Mondal; Chunying Zhao; Marjan Berishaj; Phani Ghanakota; Connie Lee Batlevi; Ahmet Dogan; Venkatraman E Seshan; Robert Abel; Michael R Green; Anas Younes; Hans-Guido Wendel
Journal:  JCI Insight       Date:  2019-06-20

2.  Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.

Authors:  Jian Liu; Deodial Guiadeen; Arto Krikorian; Xiaolei Gao; James Wang; Sobhana Babu Boga; Abdul-Basit Alhassan; Younong Yu; Henry Vaccaro; Shilan Liu; Chundao Yang; Hao Wu; Alan Cooper; Jos de Man; Allard Kaptein; Kevin Maloney; Viktor Hornak; Ying-Duo Gao; Thierry O Fischmann; Hans Raaijmakers; Diep Vu-Pham; Jeremy Presland; My Mansueto; Zangwei Xu; Erica Leccese; Jie Zhang-Hoover; Ian Knemeyer; Charles G Garlisi; Nathan Bays; Peter Stivers; Philip E Brandish; Alexandra Hicks; Ronald Kim; Joseph A Kozlowski
Journal:  ACS Med Chem Lett       Date:  2015-12-19       Impact factor: 4.345

3.  Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

Authors:  Paul A Jackson; John C Widen; Daniel A Harki; Kay M Brummond
Journal:  J Med Chem       Date:  2016-12-20       Impact factor: 7.446

4.  Discovery of Novel Bruton's Tyrosine Kinase (BTK) Inhibitors Bearing a N,9-Diphenyl-9H-purin-2-amine Scaffold.

Authors:  Yang Ge; Yue Jin; Changyuan Wang; Jianbin Zhang; Zeyao Tang; Jinyong Peng; Kexin Liu; Yanxia Li; Youwen Zhou; Xiaodong Ma
Journal:  ACS Med Chem Lett       Date:  2016-09-21       Impact factor: 4.345

5.  Optimized Near-IR Fluorescent Agents for in Vivo Imaging of Btk Expression.

Authors:  Eunha Kim; Katherine S Yang; Rainer H Kohler; John M Dubach; Hannes Mikula; Ralph Weissleder
Journal:  Bioconjug Chem       Date:  2015-06-09       Impact factor: 4.774

6.  Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor.

Authors:  W Guo; R Liu; G Bhardwaj; J C Yang; C Changou; A-H Ma; A Mazloom; S Chintapalli; K Xiao; W Xiao; P Kumaresan; E Sanchez; C-T Yeh; C P Evans; R Patterson; K S Lam; H-J Kung
Journal:  Cell Death Dis       Date:  2014-09-04       Impact factor: 8.469

7.  Prolonged and tunable residence time using reversible covalent kinase inhibitors.

Authors:  J Michael Bradshaw; Jesse M McFarland; Ville O Paavilainen; Angelina Bisconte; Danny Tam; Vernon T Phan; Sergei Romanov; David Finkle; Jin Shu; Vaishali Patel; Tony Ton; Xiaoyan Li; David G Loughhead; Philip A Nunn; Dane E Karr; Mary E Gerritsen; Jens Oliver Funk; Timothy D Owens; Erik Verner; Ken A Brameld; Ronald J Hill; David M Goldstein; Jack Taunton
Journal:  Nat Chem Biol       Date:  2015-05-25       Impact factor: 15.040

8.  Single cell imaging of Bruton's tyrosine kinase using an irreversible inhibitor.

Authors:  Anna Turetsky; Eunha Kim; Rainer H Kohler; Miles A Miller; Ralph Weissleder
Journal:  Sci Rep       Date:  2014-04-24       Impact factor: 4.379

Review 9.  Reining in BTK: Interdomain Interactions and Their Importance in the Regulatory Control of BTK.

Authors:  Lauren E Kueffer; Raji E Joseph; Amy H Andreotti
Journal:  Front Cell Dev Biol       Date:  2021-06-23

10.  CTA095, a novel Etk and Src dual inhibitor, induces apoptosis in prostate cancer cells and overcomes resistance to Src inhibitors.

Authors:  Wenchang Guo; Ruiwu Liu; Gaurav Bhardwaj; Ai-Hong Ma; Chun Changou; Joy C Yang; Yuanpei Li; Caihong Feng; Yan Luo; Anisha Mazloom; Eduardo Sanchez; Yan Wang; Wenzhe Huang; Randen Patterson; Christopher P Evans; Kit S Lam; Hsing-Jien Kung
Journal:  PLoS One       Date:  2013-08-15       Impact factor: 3.240
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