OBJECTIVE: To assess prognostic aspects of treatment modalities for cases of hepatocellular carcinoma (HCC) with portal vein tumor thrombi (PVTT). METHOD: 121 treated cases were retrospectively divided into five groups: 1 (liver transplantation); 2 (transcatheter arterial chemoembolization); 3 (hepatectomy plus thrombectomy); 4 (hepatectomy plus thrombectomy combined with adjuvant chemobiotherapy via portal vein); and 5 (conservative treatment). The Kaplan-Meier method with difference in survival estimated by Log-rank test was used to compare between groups. RESULT: Groups 1-5 had a significantly differing median survival times of 7, 7, 10, 16, 3 months (P<0.05), respectively. One- and three-year survival rates were 30.0% and 10.0%, 20.0% and 0.0%, 47.0% and 22.0%, 70% and 20%, and 12% and 4%. CONCLUSION: Surgical resection combined with adjuvant chemotherapy via the portal vein is an effective and safe treatment modality for hepatocellular carcinoma with portal vein tumor thrombi.
OBJECTIVE: To assess prognostic aspects of treatment modalities for cases of hepatocellular carcinoma (HCC) with portal vein tumor thrombi (PVTT). METHOD: 121 treated cases were retrospectively divided into five groups: 1 (liver transplantation); 2 (transcatheter arterial chemoembolization); 3 (hepatectomy plus thrombectomy); 4 (hepatectomy plus thrombectomy combined with adjuvant chemobiotherapy via portal vein); and 5 (conservative treatment). The Kaplan-Meier method with difference in survival estimated by Log-rank test was used to compare between groups. RESULT: Groups 1-5 had a significantly differing median survival times of 7, 7, 10, 16, 3 months (P<0.05), respectively. One- and three-year survival rates were 30.0% and 10.0%, 20.0% and 0.0%, 47.0% and 22.0%, 70% and 20%, and 12% and 4%. CONCLUSION: Surgical resection combined with adjuvant chemotherapy via the portal vein is an effective and safe treatment modality for hepatocellular carcinoma with portal vein tumor thrombi.
Authors: Kang Wang; Wei Xing Guo; Min Shan Chen; Yi Lei Mao; Bei Cheng Sun; Jie Shi; Yao Jun Zhang; Yan Meng; Ye Fa Yang; Wen Ming Cong; Meng Chao Wu; Wan Yee Lau; Shu Qun Cheng Journal: Medicine (Baltimore) Date: 2016-03 Impact factor: 1.889
Authors: Dai Hoon Han; Dong Jin Joo; Myoung Soo Kim; Gi Hong Choi; Jin Sub Choi; Young Nyun Park; Jinsil Seong; Kwang Hyub Han; Soon Il Kim Journal: Yonsei Med J Date: 2016-09 Impact factor: 2.759