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Literature DB >> 22393539

Leucine-rich repeat kinase 2 for beginners: six key questions.

Abstract

There has been intense interest in leucine-rich repeat kinase 2 (LRRK2) since 2004, when mutations in the LRRK2 gene were discovered to cause dominantly inherited Parkinson's disease (PD). This article will address six basic questions about LRRK2 biology as it relates to PD, with particular emphasis on its discovery, current concepts of its physiological and pathological functions, and the strategies being used to discover how LRRK2 dysfunction causes PD.

Entities: Disease Gene

Mesh：

Substances：

Year: 2012 PMID： 22393539 PMCID： PMC3282500 DOI： 10.1101/cshperspect.a009407

Source DB: PubMed Journal: Cold Spring Harb Perspect Med ISSN： 2157-1422 Impact factor: 6.915

73 in total

Review 1. 14-3-3 proteins: active cofactors in cellular regulation by serine/threonine phosphorylation.

Authors: Guri Tzivion; Joseph Avruch
Journal: J Biol Chem Date: 2001-11-14 Impact factor: 5.157

2. G2019S LRRK2 mutation causing Parkinson's disease without Lewy bodies.

Authors: Carles Gaig; María José Martí; Mario Ezquerra; Adriana Cardozo; Maria Jesus Rey; Eduardo Tolosa
Journal: BMJ Case Rep Date: 2009-01-23

Review 3. LRRK2: a common pathway for parkinsonism, pathogenesis and prevention?

Authors: Julie P Taylor; Ignacio F Mata; Matt J Farrer
Journal: Trends Mol Med Date: 2006-01-10 Impact factor: 11.951

4. Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism.

Authors: Owen A Ross; Cleanthe Spanaki; Alida Griffith; Chin-Hsien Lin; Jennifer Kachergus; Kristoffer Haugarvoll; Helen Latsoudis; Andreas Plaitakis; Joaquim J Ferreira; Cristina Sampaio; Vincenzo Bonifati; Ruey-Meei Wu; Cyrus P Zabetian; Matthew J Farrer
Journal: Parkinsonism Relat Disord Date: 2008-10-26 Impact factor: 4.891

5. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila.

Authors: Yuzuru Imai; Stephan Gehrke; Hua-Qin Wang; Ryosuke Takahashi; Kazuko Hasegawa; Etsuro Oota; Bingwei Lu
Journal: EMBO J Date: 2008-08-14 Impact factor: 11.598

6. Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase.

Authors: Junpeng Deng; Patrick A Lewis; Elisa Greggio; Eli Sluch; Alexandra Beilina; Mark R Cookson
Journal: Proc Natl Acad Sci U S A Date: 2008-01-29 Impact factor: 11.205

7. The R1441C mutation of LRRK2 disrupts GTP hydrolysis.

Authors: Patrick A Lewis; Elisa Greggio; Alexandra Beilina; Shushant Jain; Acacia Baker; Mark R Cookson
Journal: Biochem Biophys Res Commun Date: 2007-04-10 Impact factor: 3.575

8. Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers.

Authors: C Marras; B Schüle; B Schuele; R P Munhoz; E Rogaeva; J W Langston; M Kasten; C Meaney; C Klein; P M Wadia; S-Y Lim; R S-I Chuang; C Zadikof; T Steeves; K M Prakash; R M A de Bie; G Adeli; T Thomsen; K K Johansen; H A Teive; A Asante; W Reginold; A E Lang
Journal: Neurology Date: 2011-07-13 Impact factor: 9.910

9. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease.

Authors: Byoung Dae Lee; Joo-Ho Shin; Jackalina VanKampen; Leonard Petrucelli; Andrew B West; Han Seok Ko; Yun-Il Lee; Kathleen A Maguire-Zeiss; William J Bowers; Howard J Federoff; Valina L Dawson; Ted M Dawson
Journal: Nat Med Date: 2010-08-22 Impact factor: 53.440

10. LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice.

Authors: Martin C Herzig; Carine Kolly; Elke Persohn; Diethilde Theil; Tatjana Schweizer; Thomas Hafner; Christine Stemmelen; Thomas J Troxler; Peter Schmid; Simone Danner; Christian R Schnell; Matthias Mueller; Bernd Kinzel; Armelle Grevot; Federico Bolognani; Martina Stirn; Rainer R Kuhn; Klemens Kaupmann; P Herman van der Putten; Giorgio Rovelli; Derya R Shimshek
Journal: Hum Mol Genet Date: 2011-08-09 Impact factor: 6.150

23 in total

Review 1. LRRK2 in Parkinson disease: challenges of clinical trials.

Authors: Eduardo Tolosa; Miquel Vila; Christine Klein; Olivier Rascol
Journal: Nat Rev Neurol Date: 2020-01-24 Impact factor: 42.937

Review 2. LRRK2 pathobiology in Parkinson's disease.

Authors: Ian Martin; Jungwoo Wren Kim; Valina L Dawson; Ted M Dawson
Journal: J Neurochem Date: 2014-10-10 Impact factor: 5.372

Review 3. Role of the endolysosomal system in Parkinson's disease.

Authors: D J Vidyadhara; John E Lee; Sreeganga S Chandra
Journal: J Neurochem Date: 2019-07-31 Impact factor: 5.372

Review 4. LRRK2 mutations and neurotoxicant susceptibility.

Authors: Jang-Won Lee; Jason R Cannon
Journal: Exp Biol Med (Maywood) Date: 2015-04-16

Review 5. M1 and M2 immune activation in Parkinson's Disease: Foe and ally?

Authors: M S Moehle; A B West
Journal: Neuroscience Date: 2014-11-25 Impact factor: 3.590

Review 6. Autophagy in health and disease: From molecular mechanisms to therapeutic target.

Authors: Guang Lu; Yu Wang; Yin Shi; Zhe Zhang; Canhua Huang; Weifeng He; Chuang Wang; Han-Ming Shen
Journal: MedComm (2020) Date: 2022-07-10

7. Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.

Authors: Mariet Allen; Jeremy D Burgess; Travis Ballard; Daniel Serie; Xue Wang; Curtis S Younkin; Zhifu Sun; Naomi Kouri; Saurabh Baheti; Chen Wang; Minerva M Carrasquillo; Thuy Nguyen; Sarah Lincoln; Kimberly Malphrus; Melissa Murray; Todd E Golde; Nathan D Price; Steven G Younkin; Gerard D Schellenberg; Yan Asmann; Tamas Ordog; Julia Crook; Dennis Dickson; Nilüfer Ertekin-Taner
Journal: Acta Neuropathol Date: 2016-04-26 Impact factor: 17.088