OBJECTIVE: The purpose of this trial was to investigate whether breast milk (either breastfed or bottle-fed) has a better analgesic effect than sucrose in newborns born at a postmenstrual age between 32 and 37 weeks. METHODS: We conducted a randomized controlled trial at a secondary care neonatal unit in the Netherlands on 71 preterm neonates (postmenstrual age at birth 32-37 weeks), undergoing heel lance with an automated piercing device. Newborns were randomly assigned to breast milk (either breastfed or bottle-fed) administered during heel lance or oral sucrose administered before heel lance. We assessed the Premature Infant Pain Profile (PIPP) score (range, 0-21) to investigate whether there was a difference in pain score between neonates receiving breast milk and those receiving sucrose solution. RESULTS: There was no significant difference in mean PIPP score between neonates receiving breast milk (6.1) and those receiving sucrose (5.5), with a mean difference of 0.6 (95% confidence interval -1.6 to 2.8; P = .58). CONCLUSIONS: From this study, it cannot be concluded that breast milk has a better analgesic effect than sucrose in late preterm infants. From the results, it follows with 95% confidence that the analgesic effect of breast milk is not >1.6 points better and not > 2.8 points worse on the PIPP scale (SD 3.7) than the analgesic effect of sucrose in late preterm infants.
RCT Entities:
OBJECTIVE: The purpose of this trial was to investigate whether breast milk (either breastfed or bottle-fed) has a better analgesic effect than sucrose in newborns born at a postmenstrual age between 32 and 37 weeks. METHODS: We conducted a randomized controlled trial at a secondary care neonatal unit in the Netherlands on 71 preterm neonates (postmenstrual age at birth 32-37 weeks), undergoing heel lance with an automated piercing device. Newborns were randomly assigned to breast milk (either breastfed or bottle-fed) administered during heel lance or oral sucrose administered before heel lance. We assessed the Premature InfantPain Profile (PIPP) score (range, 0-21) to investigate whether there was a difference in pain score between neonates receiving breast milk and those receiving sucrose solution. RESULTS: There was no significant difference in mean PIPP score between neonates receiving breast milk (6.1) and those receiving sucrose (5.5), with a mean difference of 0.6 (95% confidence interval -1.6 to 2.8; P = .58). CONCLUSIONS: From this study, it cannot be concluded that breast milk has a better analgesic effect than sucrose in late preterm infants. From the results, it follows with 95% confidence that the analgesic effect of breast milk is not >1.6 points better and not > 2.8 points worse on the PIPP scale (SD 3.7) than the analgesic effect of sucrose in late preterm infants.
Authors: Rebeccah Slater; Caroline Hartley; Fiona Moultrie; Eleri Adams; Ed Juszczak; Richard Rogers; Jane E Norman; Chetan Patel; Kayleigh Stanbury; Amy Hoskin; Gabrielle Green Journal: Wellcome Open Res Date: 2016-11-15
Authors: Maria M Cobo; Fiona Moultrie; Annalisa G V Hauck; Daniel Crankshaw; Vaneesha Monk; Caroline Hartley; Ria Evans Fry; Shellie Robinson; Marianne van der Vaart; Luke Baxter; Eleri Adams; Ravi Poorun; Aomesh Bhatt; Rebeccah Slater Journal: BMJ Open Date: 2022-07-19 Impact factor: 3.006
Authors: Cian Wade; John Scott Frazer; Evelyn Qian; Lien M Davidson; Suzanne Dash; Anna Te Water Naudé; Rema Ramakrishan; Jalemba Aluvaala; Kokila Lakhoo; Mike English Journal: Lancet Child Adolesc Health Date: 2020-07-28