| Literature DB >> 22391326 |
K M Holwerda1, E M Bos, A Rajakumar, C Ris-Stalpers, M G van Pampus, A Timmer, J J H M Erwich, M M Faas, H van Goor, A T Lely.
Abstract
Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H(2)S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H(2)S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H(2)S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H(2)S-production and may aid in the anti-angiogenic state.Entities:
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Year: 2012 PMID： 22391326 DOI： 10.1016/j.placenta.2012.02.014
Source DB: PubMed Journal: Placenta ISSN： 0143-4004 Impact factor: 3.481