Sarah K Wise1, Rodney J Schlosser. 1. Department of Otolaryngology-Head and Neck Surgery, Emory University, Atlanta, Georgia, USA.
Abstract
BACKGROUND: Increasing interest in sublingual immunotherapy (SLIT) among practitioners and patients has resulted in numerous publications and clinical trials in recent years. With the clinical growth of SLIT, discussions of its efficacy, safety, and immunologic effects have intensified, as have comparisons to subcutaneous immunotherapy (SCIT). In the United States, SCIT has been the traditional form of immunotherapy for inhalant allergy and is the only immunotherapy method approved by the U.S. Food and Drug Administration at this time. The similarities and differences between SLIT and SCIT are often discussed, yet clinical studies directly comparing these immunotherapy methods are scarce. METHODS: A literature review of specific issues and controversies between SLIT and SCIT for allergic rhinitis was conducted. RESULTS: Safety, efficacy, and immunologic effects of these two immunotherapy techniques are reviewed. CONCLUSION: Unanswered questions relating to SLIT are examined.
BACKGROUND: Increasing interest in sublingual immunotherapy (SLIT) among practitioners and patients has resulted in numerous publications and clinical trials in recent years. With the clinical growth of SLIT, discussions of its efficacy, safety, and immunologic effects have intensified, as have comparisons to subcutaneous immunotherapy (SCIT). In the United States, SCIT has been the traditional form of immunotherapy for inhalant allergy and is the only immunotherapy method approved by the U.S. Food and Drug Administration at this time. The similarities and differences between SLIT and SCIT are often discussed, yet clinical studies directly comparing these immunotherapy methods are scarce. METHODS: A literature review of specific issues and controversies between SLIT and SCIT for allergic rhinitis was conducted. RESULTS: Safety, efficacy, and immunologic effects of these two immunotherapy techniques are reviewed. CONCLUSION: Unanswered questions relating to SLIT are examined.
Authors: Thomas M Kündig; Ludger Klimek; Philipp Schendzielorz; Wolfgang A Renner; Gabriela Senti; Martin F Bachmann Journal: Curr Treat Options Allergy Date: 2015
Authors: F Moreno Benítez; M Espinazo Romeu; A Letrán Camacho; S Mas; F J García-Cózar; A I Tabar Journal: Allergy Date: 2015-09-11 Impact factor: 13.146
Authors: Ludger Klimek; Thomas Kündig; Matthias F Kramer; Sonja Guethoff; Erika Jensen-Jarolim; Carsten B Schmidt-Weber; Oskar Palomares; Mona O Mohsen; Thilo Jakob; Martin Bachmann Journal: Allergo J Int Date: 2018-07-09