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Literature DB >> 22390946

Impact of 5-HT₃ receptor antagonists on peripheral and central diseases.

Gohar Fakhfouri¹, Reza Rahimian, Jean-Eric Ghia, Waliul I Khan, Ahmad R Dehpour.

Abstract

In this article we discuss the novel pharmacological aspects of 5-HT(3) receptor antagonists. Commonly used to counteract chemotherapy-induced emesis, these agents now appear to be reaching out for newer indications. Studies have reported neuroprotective and anti-inflammatory properties in vitro and in vivo. 5-HT(3) receptor antagonists can modulate the immune-inflammatory axis through blockade of 5-HT(3) receptors present on immune cells. We review evidence addressing the effects of these drugs on peripheral inflammatory diseases, including asthma, rheumatoid diseases, inflammatory bowel disease and sepsis in addition to diabetes and CNS disorders, including Alzheimer's disease (AD), seizure and stroke.

Entities: Disease

Mesh：

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Year: 2012 PMID： 22390946 DOI： 10.1016/j.drudis.2012.02.009

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

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Cited

17 in total

Review 1. From Chemotherapy-Induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT3 Receptor Antagonists.

Authors: Gohar Fakhfouri; Kazem Mousavizadeh; Sharam Ejtemaei Mehr; Ahmad Reza Dehpour; Mohammad Reza Zirak; Jean-Eric Ghia; Reza Rahimian
Journal: Mol Neurobiol Date: 2014-11-07 Impact factor: 5.590

Review 2. Microglial Inflammatory-Metabolic Pathways and Their Potential Therapeutic Implication in Major Depressive Disorder.

Authors: Reza Rahimian; Claudia Belliveau; Rebecca Chen; Naguib Mechawar
Journal: Front Psychiatry Date: 2022-06-16 Impact factor: 5.435

Review 3. The role of serotonin in memory: interactions with neurotransmitters and downstream signaling.

Authors: Mohammad Seyedabadi; Gohar Fakhfouri; Vahid Ramezani; Shahram Ejtemaei Mehr; Reza Rahimian
Journal: Exp Brain Res Date: 2014-01-16 Impact factor: 1.972

4. The Role of Hippocampal 5HT3 Receptors in Harmaline-Induced Memory Deficit.

Authors: Mohammad Nasehi
Journal: Basic Clin Neurosci Date: 2015-07

5. Prediction of multi-target networks of neuroprotective compounds with entropy indices and synthesis, assay, and theoretical study of new asymmetric 1,2-rasagiline carbamates.

Authors: Francisco J Romero Durán; Nerea Alonso; Olga Caamaño; Xerardo García-Mera; Matilde Yañez; Francisco J Prado-Prado; Humberto González-Díaz
Journal: Int J Mol Sci Date: 2014-09-24 Impact factor: 5.923

Review 6. The serotonergic system and cognitive function.

Authors: Dubravka Švob Štrac; Nela Pivac; Dorotea Mück-Šeler
Journal: Transl Neurosci Date: 2016-05-09 Impact factor: 1.757

Review 7. Monoaminergic and Histaminergic Strategies and Treatments in Brain Diseases.

Authors: Giuseppe Di Giovanni; Dubravka Svob Strac; Montse Sole; Mercedes Unzeta; Keith F Tipton; Dorotea Mück-Šeler; Irene Bolea; Laura Della Corte; Matea Nikolac Perkovic; Nela Pivac; Ilse J Smolders; Anna Stasiak; Wieslawa A Fogel; Philippe De Deurwaerdère
Journal: Front Neurosci Date: 2016-11-24 Impact factor: 4.677