Literature DB >> 22390164

Mutual co-regulation between GPI-N-acetylglucosaminyltransferase and ergosterol biosynthesis in Candida albicans.

Guiliana Soraya Victoria1, Bhawna Yadav, Lalremruata Hauhnar, Priyanka Jain, Shilpi Bhatnagar, Sneha Sudha Komath.   

Abstract

A novel co-regulation exists between the first step of GPI (glycosylphosphatidylinositol) anchor biosynthesis and the rate-determining step of ergosterol biosynthesis in Candida albicans. Depleting CaGpi19p, an accessory subunit of the enzyme complex that initiates GPI biosynthesis, down-regulates ERG11, altering ergosterol levels and drug response. This effect is specific to CaGpi19p depletion and is not due to cell wall defects or GPI deficiency. Additionally, down-regulation of ERG11 down-regulates CaGPI19 and GPI biosynthesis.

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Year:  2012        PMID： 22390164     DOI： 10.1042/BJ20120143

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  6 in total

1.  First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans.

Authors:  Bhawna Yadav; Shilpi Bhatnagar; Mohammad Faiz Ahmad; Priyanka Jain; Vavilala A Pratyusha; Pravin Kumar; Sneha Sudha Komath
Journal:  J Biol Chem       Date:  2013-12-19       Impact factor: 5.157

2.  Saccharomyces cerevisiae Gpi2, an accessory subunit of the enzyme catalyzing the first step of glycosylphosphatidylinositol (GPI) anchor biosynthesis, selectively complements some of the functions of its homolog in Candida albicans.

Authors:  Anshuman Yadav; Sneh Lata Singh; Bhawna Yadav; Sneha Sudha Komath
Journal:  Glycoconj J       Date:  2014-08-13       Impact factor: 2.916

3.  Ras signaling activates glycosylphosphatidylinositol (GPI) anchor biosynthesis via the GPI-N-acetylglucosaminyltransferase (GPI-GnT) in Candida albicans.

Authors:  Priyanka Jain; Subhash Chandra Sethi; Vavilala A Pratyusha; Pramita Garai; Nilofer Naqvi; Sonali Singh; Kalpana Pawar; Niti Puri; Sneha Sudha Komath
Journal:  J Biol Chem       Date:  2018-06-15       Impact factor: 5.157

4.  Ascorbic acid inhibition of Candida albicans Hsp90-mediated morphogenesis occurs via the transcriptional regulator Upc2.

Authors:  Frédérique Van Hauwenhuyse; Alessandro Fiori; Patrick Van Dijck
Journal:  Eukaryot Cell       Date:  2014-08-01

Review 5.  Targeting the GPI biosynthetic pathway.

Authors:  Usha Yadav; Mohd Ashraf Khan
Journal:  Pathog Glob Health       Date:  2018-02-27       Impact factor: 2.894

6.  Ras hyperactivation versus overexpression: Lessons from Ras dynamics in Candida albicans.

Authors:  Vavilala A Pratyusha; Guiliana Soraya Victoria; Mohammad Firoz Khan; Dominic T Haokip; Bhawna Yadav; Nibedita Pal; Subhash Chandra Sethi; Priyanka Jain; Sneh Lata Singh; Sobhan Sen; Sneha Sudha Komath
Journal:  Sci Rep       Date:  2018-03-27       Impact factor: 4.379
  6 in total

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