Literature DB >> 22389215

The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development.

Yonatan Feuermann1, Gertraud W Robinson, Bing-Mei Zhu, Keunsoo Kang, Noa Raviv, Daisuke Yamaji, Lothar Hennighausen.   

Abstract

Genome wide analysis revealed the miR-17/92 cluster as a STAT5 target. This cluster encodes six microRNAs, which predictably target genes that play a role in mammary gland development. In this study, we have deleted the miR-17/92 cluster in mammary stem cells and evaluated in the mouse its function during mammary gland development. Loss of the miR-17/92 cluster did not affect mammary development from prepuberty to lactation. Our studies demonstrated that, while expression of the miR-17/92 cluster is under control of the key mammary transcription factor STAT5, its presence is not required for normal mammary development or lactation.
Copyright © 2012 Wiley Periodicals, Inc.

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Year:  2012        PMID： 22389215      PMCID： PMC3560854          DOI： 10.1002/dvg.22023

Source DB:  PubMed          Journal:  Genesis        ISSN： 1526-954X            Impact factor:   2.487


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