Literature DB >> 22389056

Anti-inflammatory effect of piperine in adjuvant-induced arthritic rats--a biochemical approach.

Vachana Murunikkara1, Samuel Joshua Pragasam, Geema Kodandaraman, Evan Prince Sabina, MahaboobKhan Rasool.   

Abstract

The present study was undertaken to investigate the anti-inflammatory effect of piperine against adjuvant-induced arthritis in rats, an experimental model for rheumatoid arthritis and compared it with that of the non-steroidal anti-inflammatory drug indomethacin. Administration of heat-killed Mycobacterium tuberculosis (0. 1 ml) intradermally into the right hind paw of rats resulted in increased paw volume, lysosomal enzymes, glycoproteins and tissue marker enzymes and decreased body weight. However, these changes were reverted to near normal levels upon piperine (30 mg/kg body weight, i.p.) treatment. Histopathological analysis of joints also revealed that synovial hyperplasia and mononuclear infiltration observed in arthritic rats were alleviated by piperine. Thus, the present study clearly indicated that piperine possesses promising anti-inflammatory effect against adjuvant-induced arthritis by suppressing inflammation and cartilage destruction.

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Year:  2012        PMID： 22389056     DOI： 10.1007/s10753-012-9448-3

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  24 in total

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Journal:  Chem Biol Interact       Date:  2005-10-20       Impact factor: 5.192

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Journal:  Arthritis Rheum       Date:  1969-10

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Journal:  Biochem Med       Date:  1983-04

Review 6.  Therapeutic potential of kava in the treatment of anxiety disorders.

Authors:  Yadhu N Singh; Nirbhay N Singh
Journal:  CNS Drugs       Date:  2002       Impact factor: 5.749

7.  A role of piperine on monosodium urate crystal-induced inflammation--an experimental model of gouty arthritis.

Authors:  Evan Prince Sabina; Shruthi Nagar; Mahaboobkhan Rasool
Journal:  Inflammation       Date:  2011-06       Impact factor: 4.092

8.  A high yield preparation for rat kidney brush border membranes. Different behaviour of lysosomal markers.

Authors:  J Biber; B Stieger; W Haase; H Murer
Journal:  Biochim Biophys Acta       Date:  1981-10-02

9.  Immunomodulatory and antitumor activity of Piper longum Linn. and piperine.

Authors:  E S Sunila; G Kuttan
Journal:  J Ethnopharmacol       Date:  2004-02       Impact factor: 4.360

10.  Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models.

Authors:  Jun Soo Bang; Da Hee Oh; Hyun Mi Choi; Bong-Jun Sur; Sung-Jig Lim; Jung Yeon Kim; Hyung-In Yang; Myung Chul Yoo; Dae-Hyun Hahm; Kyoung Soo Kim
Journal:  Arthritis Res Ther       Date:  2009-03-30       Impact factor: 5.156
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  7 in total

1.  Piperine Suppresses the Expression of CXCL8 in Lipopolysaccharide-Activated SW480 and HT-29 Cells via Downregulating the Mitogen-Activated Protein Kinase Pathways.

Authors:  Xiao-Feng Hou; Hao Pan; Li-Hui Xu; Qing-Bing Zha; Xian-Hui He; Dong-Yun Ouyang
Journal:  Inflammation       Date:  2015       Impact factor: 4.092

2.  Majoon ushba, a polyherbal compound, suppresses pro-inflammatory mediators and RANKL expression via modulating NFкB and MAPKs signaling pathways in fibroblast-like synoviocytes from adjuvant-induced arthritic rats.

Authors:  Ramamoorthi Ganesan; Hari Madhuri Doss; Mahaboobkhan Rasool
Journal:  Immunol Res       Date:  2016-08       Impact factor: 2.829

3.  Piperine Suppresses Pyroptosis and Interleukin-1β Release upon ATP Triggering and Bacterial Infection.

Authors:  Yi-Dan Liang; Wen-Jing Bai; Chen-Guang Li; Li-Hui Xu; Hong-Xia Wei; Hao Pan; Xian-Hui He; Dong-Yun Ouyang
Journal:  Front Pharmacol       Date:  2016-10-20       Impact factor: 5.810

4.  FM0807 decelerates experimental arthritis progression by inhibiting inflammatory responses and joint destruction via modulating NF-κB and MAPK pathways.

Authors:  Nanwen Zhang; Zhiwei Liu; Hongbin Luo; Weifang Wu; Kaimei Nie; Lin Cai; Shuangyu Tan; Xiaole Chen; Ying Huang; Jiaxing Liu; Meina Lv; Xin Zhang; Yun Fan; Yuying Lin; Shennan Ye; Yang Liu; Lixian Wu; Jianhua Xu
Journal:  Biosci Rep       Date:  2019-09-03       Impact factor: 3.840

5.  Enhanced Bioavailability of Boswellic Acid by Piper longum: A Computational and Pharmacokinetic Study.

Authors:  K Reeta Vijayarani; Manoj Govindarajulu; Sindhu Ramesh; Mansour Alturki; Mohammed Majrashi; Ayaka Fujihashi; Mohammed Almaghrabi; N Kirubakaran; Jun Ren; R Jayachandra Babu; Forrest Smith; Timothy Moore; Muralikrishnan Dhanasekaran
Journal:  Front Pharmacol       Date:  2020-12-15       Impact factor: 5.810

6.  Piperine Improves Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats Through its Neuroprotective, Anti-inflammatory, and Antioxidant Effects.

Authors:  Reza Nasrnezhad; Sohrab Halalkhor; Farzin Sadeghi; Fereshteh Pourabdolhossein
Journal:  Mol Neurobiol       Date:  2021-08-02       Impact factor: 5.590

7.  Protective efficacy of N-(2-hydroxyphenyl) acetamide against adjuvant-induced arthritis in rats.

Authors:  Kahkashan Perveen; Farina Hanif; Huma Jawed; Shabana U Simjee
Journal:  Biomed Res Int       Date:  2013-07-18       Impact factor: 3.411
  7 in total

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