Literature DB >> 22389014

LC-MS data processing with MAVEN: a metabolomic analysis and visualization engine.

Michelle F Clasquin1, Eugene Melamud, Joshua D Rabinowitz.   

Abstract

MAVEN is an open-source software program for interactive processing of LC-MS-based metabolomics data. MAVEN enables rapid and reliable metabolite quantitation from multiple reaction monitoring data or high-resolution full-scan mass spectrometry data. It automatically detects and reports peak intensities for isotope-labeled metabolites. Menu-driven, click-based navigation allows visualization of raw and analyzed data. Here we provide a User Guide for MAVEN. Step-by-step instructions are provided for data import, peak alignment across samples, identification of metabolites that differ strongly between biological conditions, quantitation and visualization of isotope-labeling patterns, and export of tables of metabolite-specific peak intensities. Together, these instructions describe a workflow that allows efficient processing of raw LC-MS data into a form ready for biological analysis.

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Year:  2012        PMID： 22389014      PMCID： PMC4055029          DOI： 10.1002/0471250953.bi1411s37

Source DB:  PubMed          Journal:  Curr Protoc Bioinformatics        ISSN： 1934-3396


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