PURPOSE OF REVIEW: To give an overview of the current knowledge on assay techniques and clinical implications of immunogenicity of biological therapeutics. RECENT FINDINGS: Assay techniques for the measurement of immunogenicity have improved, expanding the understanding of the immune response against biological therapeutics. Knowledge on the clinical effect of immunogenicity enables the treatment of patients in a targeted fashion, as a step towards personalized medicine. SUMMARY: Biological medications are able to induce an antidrug immune response. Immunogenicity impairs clinical response and is associated with adverse events. Several confounding factors influence the measurement of immunogenicity, including drug interference and background problems. Concomitant administration of methotrexate lowers the frequency and amount of antibodies formed, whereby the efficacy of biologicals is improved. Algorithms for therapeutic drug monitoring could aid in adapting treatment strategies in a controlled setting.
PURPOSE OF REVIEW: To give an overview of the current knowledge on assay techniques and clinical implications of immunogenicity of biological therapeutics. RECENT FINDINGS: Assay techniques for the measurement of immunogenicity have improved, expanding the understanding of the immune response against biological therapeutics. Knowledge on the clinical effect of immunogenicity enables the treatment of patients in a targeted fashion, as a step towards personalized medicine. SUMMARY: Biological medications are able to induce an antidrug immune response. Immunogenicity impairs clinical response and is associated with adverse events. Several confounding factors influence the measurement of immunogenicity, including drug interference and background problems. Concomitant administration of methotrexate lowers the frequency and amount of antibodies formed, whereby the efficacy of biologicals is improved. Algorithms for therapeutic drug monitoring could aid in adapting treatment strategies in a controlled setting.
Authors: Eva L Kneepkens; Mieke F Pouw; Gerrit Jan Wolbink; Tiny Schaap; Michael T Nurmohamed; Annick de Vries; Theo Rispens; Karien Bloem Journal: Br J Clin Pharmacol Date: 2017-08-22 Impact factor: 4.335
Authors: Roberto A Maldonado; Robert A LaMothe; Joseph D Ferrari; Ai-Hong Zhang; Robert J Rossi; Pallavi N Kolte; Aaron P Griset; Conlin O'Neil; David H Altreuter; Erica Browning; Lloyd Johnston; Omid C Farokhzad; Robert Langer; David W Scott; Ulrich H von Andrian; Takashi Kei Kishimoto Journal: Proc Natl Acad Sci U S A Date: 2014-12-29 Impact factor: 11.205