Literature DB >> 22387462

Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities.

Halil Uzuner1, Rudolf Bauer, Tai-Ping Fan, De-An Guo, Alberto Dias, Hani El-Nezami, Thomas Efferth, Elizabeth M Williamson, Michael Heinrich, Nicola Robinson, Peter J Hylands, Bruce M Hendry, Yung-Chi Cheng, Qihe Xu.   

Abstract

BACKGROUND AND AIMS: GP-TCM is the 1st EU-funded Coordination Action consortium dedicated to traditional Chinese medicine (TCM) research. This paper aims to summarise the objectives, structure and activities of the consortium and introduces the position of the consortium regarding good practice, priorities, challenges and opportunities in TCM research. Serving as the introductory paper for the GP-TCM Journal of Ethnopharmacology special issue, this paper describes the roadmap of this special issue and reports how the main outputs of the ten GP-TCM work packages are integrated, and have led to consortium-wide conclusions.
MATERIALS AND METHODS: Literature studies, opinion polls and discussions among consortium members and stakeholders.
RESULTS: By January 2012, through 3 years of team building, the GP-TCM consortium had grown into a large collaborative network involving ∼200 scientists from 24 countries and 107 institutions. Consortium members had worked closely to address good practice issues related to various aspects of Chinese herbal medicine (CHM) and acupuncture research, the focus of this Journal of Ethnopharmacology special issue, leading to state-of-the-art reports, guidelines and consensus on the application of omics technologies in TCM research. In addition, through an online survey open to GP-TCM members and non-members, we polled opinions on grand priorities, challenges and opportunities in TCM research. Based on the poll, although consortium members and non-members had diverse opinions on the major challenges in the field, both groups agreed that high-quality efficacy/effectiveness and mechanistic studies are grand priorities and that the TCM legacy in general and its management of chronic diseases in particular represent grand opportunities. Consortium members cast their votes of confidence in omics and systems biology approaches to TCM research and believed that quality and pharmacovigilance of TCM products are not only grand priorities, but also grand challenges. Non-members, however, gave priority to integrative medicine, concerned on the impact of regulation of TCM practitioners and emphasised intersectoral collaborations in funding TCM research, especially clinical trials.
CONCLUSIONS: The GP-TCM consortium made great efforts to address some fundamental issues in TCM research, including developing guidelines, as well as identifying priorities, challenges and opportunities. These consortium guidelines and consensus will need dissemination, validation and further development through continued interregional, interdisciplinary and intersectoral collaborations. To promote this, a new consortium, known as the GP-TCM Research Association, is being established to succeed the 3-year fixed term FP7 GP-TCM consortium and will be officially launched at the Final GP-TCM Congress in Leiden, the Netherlands, in April 2012.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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Year:  2012        PMID: 22387462     DOI: 10.1016/j.jep.2012.02.028

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN: 0378-8741            Impact factor:   4.360


  14 in total

Review 1.  An overview on adverse drug reactions to traditional Chinese medicines.

Authors:  Kelvin Chan; Hongwei Zhang; Zhi-Xiu Lin
Journal:  Br J Clin Pharmacol       Date:  2015-05-19       Impact factor: 4.335

2.  Evaluation of phenolic contents and antioxidant activities of brown seaweeds belonging to Turbinaria spp. (Phaeophyta, Sargassaceae) collected from Gulf of Mannar.

Authors:  Kajal Chakraborty; Nammunayathuputhenkotta Krishnankartha Praveen; Kodayan Kizekadath Vijayan; Gonugontla Syda Rao
Journal:  Asian Pac J Trop Biomed       Date:  2013-01

3.  A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells.

Authors:  Ke-Jia Wu; Jie-Min Huang; Hai-Jing Zhong; Zhen-Zhen Dong; Kasipandi Vellaisamy; Jin-Jian Lu; Xiu-Ping Chen; Pauline Chiu; Daniel W J Kwong; Quan-Bin Han; Dik-Lung Ma; Chung-Hang Leung
Journal:  PLoS One       Date:  2017-06-01       Impact factor: 3.240

Review 4.  Application of metabolomics in toxicity evaluation of traditional Chinese medicines.

Authors:  Li Duan; Long Guo; Lei Wang; Qiang Yin; Chen-Meng Zhang; Yu-Guang Zheng; E-Hu Liu
Journal:  Chin Med       Date:  2018-12-04       Impact factor: 5.455

5.  Use of Complementary Traditional Chinese Medicines by Adult Cancer Patients in Taiwan: A Nationwide Population-Based Study.

Authors:  Yi-Ting Kuo; Tung-Ti Chang; Chih-Hsin Muo; Mei-Yao Wu; Mao-Feng Sun; Chia-Chou Yeh; Hung-Rong Yen
Journal:  Integr Cancer Ther       Date:  2017-06-30       Impact factor: 3.279

6.  Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay.

Authors:  Pamela Dakik; Mélissa McAuley; Marisa Chancharoen; Darya Mitrofanova; Monica Enith Lozano Rodriguez; Jennifer Anne Baratang Junio; Vicky Lutchman; Berly Cortes; Éric Simard; Vladimir I Titorenko
Journal:  Oncotarget       Date:  2019-01-08

Review 7.  Discovery and resupply of pharmacologically active plant-derived natural products: A review.

Authors:  Atanas G Atanasov; Birgit Waltenberger; Eva-Maria Pferschy-Wenzig; Thomas Linder; Christoph Wawrosch; Pavel Uhrin; Veronika Temml; Limei Wang; Stefan Schwaiger; Elke H Heiss; Judith M Rollinger; Daniela Schuster; Johannes M Breuss; Valery Bochkov; Marko D Mihovilovic; Brigitte Kopp; Rudolf Bauer; Verena M Dirsch; Hermann Stuppner
Journal:  Biotechnol Adv       Date:  2015-08-15       Impact factor: 14.227

Review 8.  The quest for modernisation of traditional Chinese medicine.

Authors:  Qihe Xu; Rudolf Bauer; Bruce M Hendry; Tai-Ping Fan; Zhongzhen Zhao; Pierre Duez; Monique S J Simmonds; Claudia M Witt; Aiping Lu; Nicola Robinson; De-an Guo; Peter J Hylands
Journal:  BMC Complement Altern Med       Date:  2013-06-13       Impact factor: 3.659

9.  Why is Research on Herbal Medicinal Products Important and How Can We Improve Its Quality?

Authors:  Olavi Pelkonen; Qihe Xu; Tai-Ping Fan
Journal:  J Tradit Complement Med       Date:  2014-01

10.  Identifying the Species of Seeds in Traditional Chinese Medicine Using DNA Barcoding.

Authors:  Chao Xiong; Wei Sun; Jingjian Li; Hui Yao; Yuhua Shi; Ping Wang; Bisheng Huang; Linchun Shi; Di Liu; Zhigang Hu; Shilin Chen
Journal:  Front Pharmacol       Date:  2018-07-03       Impact factor: 5.810

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