BACKGROUND: Some autoimmune conditions have been associated with reduced vitamin D levels, including systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus, and multiple sclerosis. OBJECTIVE: The main objective of this study was to analyze the 25-hydroxyvitamin D (OHD) status of patients with psoriasis in comparison with control subjects without this disease. METHODS: This case-control study included 86 patients (43 with psoriasis and 43 age- and sex-matched control subjects) from the outpatient clinic of our hospital dermatology department in Granada, Spain. All patients and control subjects were studied during one 4-week period to avoid seasonal variations in vitamin D levels. RESULTS: Serum 25-OHD levels were significantly lower in psoriatic patients than in control subjects even after adjusting for confounding factors in a multivariate analysis (odds ratio 2.89, 95% confidence interval 1.02-7.64, P < .03 for vitamin D insufficiency). Low 25-OHD levels were negatively associated with C-reactive protein (inflammatory activation marker) and body mass index in multiple linear regression analysis. Psoriatic patients with body mass index greater than or equal to 27 kg/m(2) had a higher risk of 25-OHD insufficiency (sensitivity of 82.3% and specificity of 51.7%). LIMITATIONS: Further studies with larger numbers of patients are required to analyze the pathogenic mechanisms underlying the relationship between 25-OHD deficiency and psoriasis. CONCLUSIONS: The 25-OHD values are significantly lower in psoriatic patients than in control subjects. Low 25-OHD levels are negatively associated with C-reactive protein, an inflammatory activation marker, and with obesity. Psoriatic patients with a body mass index of 27 or more are likely to have vitamin D insufficiency.
BACKGROUND: Some autoimmune conditions have been associated with reduced vitamin D levels, including systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus, and multiple sclerosis. OBJECTIVE: The main objective of this study was to analyze the 25-hydroxyvitamin D (OHD) status of patients with psoriasis in comparison with control subjects without this disease. METHODS: This case-control study included 86 patients (43 with psoriasis and 43 age- and sex-matched control subjects) from the outpatient clinic of our hospital dermatology department in Granada, Spain. All patients and control subjects were studied during one 4-week period to avoid seasonal variations in vitamin D levels. RESULTS: Serum 25-OHD levels were significantly lower in psoriaticpatients than in control subjects even after adjusting for confounding factors in a multivariate analysis (odds ratio 2.89, 95% confidence interval 1.02-7.64, P < .03 for vitamin Dinsufficiency). Low 25-OHD levels were negatively associated with C-reactive protein (inflammatory activation marker) and body mass index in multiple linear regression analysis. Psoriaticpatients with body mass index greater than or equal to 27 kg/m(2) had a higher risk of 25-OHD insufficiency (sensitivity of 82.3% and specificity of 51.7%). LIMITATIONS: Further studies with larger numbers of patients are required to analyze the pathogenic mechanisms underlying the relationship between 25-OHD deficiency and psoriasis. CONCLUSIONS: The 25-OHD values are significantly lower in psoriaticpatients than in control subjects. Low 25-OHD levels are negatively associated with C-reactive protein, an inflammatory activation marker, and with obesity. Psoriaticpatients with a body mass index of 27 or more are likely to have vitamin Dinsufficiency.
Authors: Z Petho; E Kulcsar-Jakab; E Kalina; A Balogh; A Pusztai; K Gulyas; A Horvath; Z Szekanecz; H P Bhattoa Journal: Osteoporos Int Date: 2015-02-19 Impact factor: 4.507
Authors: G Bellastella; M I Maiorino; M Petrizzo; A De Bellis; A Capuano; K Esposito; D Giugliano Journal: J Endocrinol Invest Date: 2015-01-10 Impact factor: 4.256
Authors: Rodney Macedo; Chloé Pasin; Alex Ganetsky; David Harle; Ximi K Wang; Kirubel Belay; Lee P Richman; Austin P Huffman; Robert H Vonderheide; Andrew J Yates; David L Porter; Ying Wang; Yi Zhang; Ran Reshef Journal: Transplant Cell Ther Date: 2021-09-28
Authors: Amal Ahmed Mohamed; Eman Elhussain; Naglaa Fawzy; Yasser Sakr; Marwa Salah El-Dien; Abbas Mohammed Abbas; Maha S Hussein; Nourelhuda Nassar; Omnia Ezzat; Reham Yousry El-Amir; Sarah Ibrahim; Nermeen Ibrahim Bedair Journal: Clin Cosmet Investig Dermatol Date: 2022-07-07