| Literature DB >> 22386625 |
Jianguo Wu1, Xialu Yang, Juan Ge, Yiping Zhang, Lin Wu, Jianmiao Liu, Xiaoyu Zhang.
Abstract
Biotransformation of sophoricoside in Fructus sophorae was performed with Schizophyllum commune. Sophoricoside was firstly metabolized to 4',5,7-trihydroxyisoflavone (2), and then to 4',7-dihydroxy-5-methoxyisoflavone (3) and 5,7-dihydroxy-4'-methoxyisoflavone (4) as determined by NMR and MS analyzes. The content of compound (2) was increased by more than 30-fold, and compound (3) is a new product that showed good cytotoxic activity with an IC(50) of 12.1 nmol/ml against MCF-7 cells. Copyright ÂEntities:
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Year: 2012 PMID： 22386625 DOI： 10.1016/j.biortech.2012.02.038
Source DB: PubMed Journal: Bioresour Technol ISSN： 0960-8524 Impact factor: 9.642