Literature DB >> 22386528

Iodine-catalyzed condensation of isatin with indoles: a facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity.

B V Subba Reddy1, N Rajeswari, M Sarangapani, Y Prashanthi, Roopa Jones Ganji, Anthony Addlagatta.   

Abstract

Isatin reacts smoothly with indoles in the presence of a catalytic amount of molecular iodine under mild conditions to afford a novel class of di(indolyl)indolin-2-one derivatives in good yields. These molecules are found to possess a promising cytotoxicity against cancer cells only but not on normal cells.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 22386528     DOI： 10.1016/j.bmcl.2012.02.011

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Synthesis and structure-activity relationship of mono-indole-, bis-indole-, and tris-indole-based sulfonamides as potential anticancer agents.

Authors:  Ratchanok Pingaew; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul
Journal:  Mol Divers       Date:  2013-06-28       Impact factor: 2.943

2.  Alcohols as Substrates and Solvents for the Construction of 3-Alkoxylated-2-Oxindoles by Direct Alkoxylation of 3-Halooxindoles.

Authors:  Bing Lin; Zhi-Yong Chen; Huan-Huan Liu; Qi-Di Wei; Ting-Ting Feng; Ying Zhou; Can Wang; Xiong-Li Liu; Wei-Cheng Yuan
Journal:  Molecules       Date:  2017-05-13       Impact factor: 4.411

3.  Effective Synthesis and Biological Evaluation of Natural and Designed Bis(indolyl)methanes via Taurine-Catalyzed Green Approach.

Authors:  Kailas A Chavan; Manjari Shukla; Amar Nath Singh Chauhan; Sushobhan Maji; Ghanshyam Mali; Sudipta Bhattacharyya; Rohan D Erande
Journal:  ACS Omega       Date:  2022-03-16

4.  Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones.

Authors:  Mardi Santoso; Li Lin Ong; Nur Pasca Aijijiyah; First Ambar Wati; Azminah Azminah; Rose Malina Annuur; Arif Fadlan; Zaher M A Judeh
Journal:  Heliyon       Date:  2022-03-04

5.  Novel isatin-indole derivatives as potential inhibitors of chorismate mutase (CM): their synthesis along with unexpected formation of 2-indolylmethylamino benzoate ester under Pd-Cu catalysis.

Authors:  Gangireddy Sujeevan Reddy; Kazi Amirul Hossain; Jetta Sandeep Kumar; B Thirupataiah; Rebecca Kristina Edwin; Varadaraj Bhat Giliyaru; Raghu Chandrashekhar Hariharapura; G Gautham Shenoy; Parimal Misra; Manojit Pal
Journal:  RSC Adv       Date:  2020-01-02       Impact factor: 4.036

Review 6.  Chemistry of trisindolines: natural occurrence, synthesis and bioactivity.

Authors:  First Ambar Wati; Mardi Santoso; Ziad Moussa; Sri Fatmawati; Arif Fadlan; Zaher M A Judeh
Journal:  RSC Adv       Date:  2021-07-21       Impact factor: 4.036

7.  An efficient synthesis of 3-indolyl-3-hydroxy oxindoles and 3,3-di(indolyl)indolin-2-ones catalyzed by sulfonated β-CD as a supramolecular catalyst in water.

Authors:  Yogesh A Tayade; Dipak R Patil; Yogesh B Wagh; Asha D Jangle; Dipak S Dalal
Journal:  Tetrahedron Lett       Date:  2014-12-12       Impact factor: 2.415

8.  Synthesis of thiocarbohydrazide and carbohydrazide derivatives as possible biologically active agents.

Authors:  Kiran Gangarapu; Sarangapani Manda; Anvesh Jallapally; Sreekanth Thota; Subhas S Karki; Jan Balzarini; Erik De Clercq; Harukuni Tokuda
Journal:  Med Chem Res       Date:  2013-08-23       Impact factor: 1.965

9.  Silica-Coated Magnetic-Nanoparticle-Supported DABCO-Derived Acidic Ionic Liquid for the Efficient Synthesis of Bioactive 3,3-Di(indolyl)indolin-2-ones.

Authors:  Radhika Gupta; Manavi Yadav; Rashmi Gaur; Gunjan Arora; Pooja Rana; Priya Yadav; Alok Adholeya; Rakesh K Sharma
Journal:  ACS Omega       Date:  2019-12-06
  9 in total

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