| Literature DB >> 22386267 |
A Lopez de Lapuente1, I Alloza, R Goertsches, U K Zettl, E Urcelay, R Arroyo, M Comabella, X Montalban, A Antigüedad, K Vandenbroeck.
Abstract
Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.Entities:
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Year: 2012 PMID： 22386267 DOI： 10.1016/j.jneuroim.2012.02.005
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478